Pre-Omicron seroprevalence, seroconversion, and seroreversion of infection-induced SARS-CoV-2 antibodies among a cohort of children and teenagers in Montréal, Canada.

Autor:	Zinszer K; University of Montréal, Montréal, Canada; University of Montréal, Centre for Public Health Research, Montréal, Canada. Electronic address: kate.zinszer@umontreal.ca., Charland K; University of Montréal, Centre for Public Health Research, Montréal, Canada., Pierce L; University of Montréal, Centre for Public Health Research, Montréal, Canada., Saucier A; University of Montréal, Montréal, Canada; University of Montréal, Centre for Public Health Research, Montréal, Canada., McKinnon B; University of Montréal, Centre for Public Health Research, Montréal, Canada; University of Toronto, Dalla Lana School of Public Health, Toronto, Canada., Hamelin MÈ; Université Laval, Infectious Disease Research Center, Québec City, Canada., Cheriet I; University of Montréal, Montréal, Canada., Da Torre MB; University of Montréal, Montréal, Canada; University of Montréal, Centre for Public Health Research, Montréal, Canada., Carbonneau J; Université Laval, Infectious Disease Research Center, Québec City, Canada., Nguyen CT; Ministère de la santé et des services sociaux, Québec City, Canada., De Serres G; National Institute of Public Health of Québec, Québec City, Canada., Papenburg J; Montréal Children's Hospital of the McGill University Health Centre, Montréal, Canada., Boivin G; Université Laval, Infectious Disease Research Center, Québec City, Canada., Quach C; University of Montréal, Montréal, Canada; Research Centre of the Sainte-Justine University Hospital, Montréal, Canada.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2023 Jun; Vol. 131, pp. 119-126. Date of Electronic Publication: 2023 Mar 23.
DOI:	10.1016/j.ijid.2023.03.036
Abstrakt:	Objectives: To use serological testing to assess the pre-Omicron seroprevalence, seroconversion, and seroreversion of infection-induced SARS-CoV-2 antibodies in children and adolescents in Montréal, Canada. Design: This analysis is from a prospective cohort study of children aged 2-17 years (at baseline) that included blood spots for antibody detection. The serostatus of participants was determined by enzyme-linked immunosorbent assays using the receptor-binding domain from the spike protein and the nucleocapsid protein as antigens. We estimated seroprevalence, seroconversion rates, and the likelihood of seroreversion at 6 months and 1 year. Results: The baseline (October 2020 to April 2021) seroprevalence was 5.8% (95% confidence interval [CI] 4.8-7.1), which increased to 10.5% (May to September 2021) and 11.0% (November 2021 to March 2022) for the respective follow-ups (95% CI 8.6-12.7; 95% CI 8.8-13.5). The crude rate of seroconversion over the study period was 12.8 per 100 person-years (95% CI 11.0-14.7). The adjusted hazard rates of seroconversion by child characteristics showed higher rates in children who were female, whose parent identified as a racial or ethnic minority, and in households with incomes in the lowest tercile of our study population. The likelihood of remaining seropositive at 6 months was 68% (95% CI 60-77%) and dropped to 42% (95% CI 32-56%) at 1 year. Conclusion: Serological studies continue to provide valuable contributions for infection prevalence estimates and help us better understand the dynamics of antibody levels after infection. (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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