[Genetic diversity of capsid protein (p24) in human immunodeficiency virus type-1 (HIV-1) variants circulating in the Russian Federation].

Autor:	Kuznetsova AI; D.I. Ivanovsky Institute of Virology of FSBI 'National Reseach Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya'., Munchak IM; D.I. Ivanovsky Institute of Virology of FSBI 'National Reseach Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya'., Lebedev AV; D.I. Ivanovsky Institute of Virology of FSBI 'National Reseach Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya'., Tumanov AS; D.I. Ivanovsky Institute of Virology of FSBI 'National Reseach Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya'., Kim KV; D.I. Ivanovsky Institute of Virology of FSBI 'National Reseach Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya'., Antonova AA; D.I. Ivanovsky Institute of Virology of FSBI 'National Reseach Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya'., Ozhmegova EN; D.I. Ivanovsky Institute of Virology of FSBI 'National Reseach Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya'., Pronin AY; Moscow Regional Center for the Prevention and Control of AIDS and Infectious Diseases., Drobyshevskaya EV; Moscow Regional Center for the Prevention and Control of AIDS and Infectious Diseases., Kazennova EV; D.I. Ivanovsky Institute of Virology of FSBI 'National Reseach Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya'., Bobkova MR; D.I. Ivanovsky Institute of Virology of FSBI 'National Reseach Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya'.
Jazyk:	ruština
Zdroj:	Voprosy virusologii [Vopr Virusol] 2023 Mar 11; Vol. 68 (1), pp. 66-78. Date of Electronic Publication: 2023 Mar 11.
DOI:	10.36233/0507-4088-161
Abstrakt:	Introduction: The human immunodeficiency virus (HIV) protein p24 plays an important role in the life cycle of the virus, and also is a target for diagnostic tests and for new antiretroviral drugs and therapeutic vaccines. The most studied variant of HIV-1 in the world is subtype B. In Russia, the most common variant is A6, the spread of recombinant forms (CRF63_02A6, CRF03_A6B) is observed as well as circulation of G and CRF02_AG variants. However, a detailed study of the p24 protein in these variants has not yet been conducted. The aim was to study the features of the p24 protein in HIV-1 variants circulating in Russia and estimate the frequency of occurrence of pre-existing mutations associated with resistance to lenacapavir, the first antiretroviral drug in the class of capsid inhibitors. Materials and Methods: The objects of the study were the nucleotide sequences obtained from the Los Alamos international database and clinical samples from HIV infected patients. Results and Discussion: The features of HIV-1 variants circulating in Russia have been determined. V86A, H87Q, I91F are characteristic substitutions in A6 genome. It is shown that the presence of preexisting mutations associated with resistance to lenacapavir is unlikely. Conclusion: Features of the p24 protein in HIV-1 variants circulating in Russia allow them to be distinguished from others variants and among themselves. The prognosis for the use of lenacapavir in Russia is generally favorable. The results obtained could be taken into account in developing and using antiretroviral drugs and therapeutic vaccines.
Databáze:	MEDLINE
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