| Autor: |
Gavit AA; Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India., Gagrani MB; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India., Gurav SS; Department of Pharmacognosy, Goa College of Pharmacy, Panaji, India., Ayyanar M; Department of Botany, A. V. V, M. Sri Pushpam College (Affiliated to Bharathidasan University), Thanjavur, India., Beldar VG; Department of Pharmaceutical Sciences & Technology, Institute of Chemical Technology, Jalna, India., Tatiya AU; Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India., Surana SJ; Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India., Firke SD; Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India., Kalaskar MG; Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India. |
| Abstrakt: |
This work aimed to investigate the chemical composition, antioxidant activity, antinociceptive effect, and wound healing activity of the Lonicera caprifolium L. flower essential oil (LCEO). Linalool (16.42%), d-limonene (9.99%), and α-cadinol (10.65%) were the most prevalent components of the LCEO. The LCEO revealed moderate DPPH and ABTS radical-scavenging activity. LCEO exhibited potent antinociceptive activity in acetic acid-induced writhing and hot plate-induced pain model; LCEO reduced 73.88 ± 2.78% of writhing and significantly increased pain withdrawal latency in the mice, respectively. The LCEO also presented a potent wound healing effect, with 98.08 ± 1.37% wound closure on the 12th day of treatment. The results of the study demonstrate antioxidant and wound healing potential with antinociceptive effect. To the best of our knowledge, this is the first report on the bioactivities of L. caprifolium L. essential oil. |
