Co-option of epidermal cells enables touch sensing.

Autor: Mangione F; Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, London, UK. federica.mangione@crick.ac.uk., Titlow J; Department of Biochemistry, University of Oxford, Oxford, UK., Maclachlan C; Electron Microscopy Science Technology Platform, The Francis Crick Institute, London, UK., Gho M; Sorbonne Université, CNRS, Laboratoire de Biologie du Développement, Institut de Biologie Paris Seine (LBD-IBPS), Paris, France., Davis I; Department of Biochemistry, University of Oxford, Oxford, UK., Collinson L; Electron Microscopy Science Technology Platform, The Francis Crick Institute, London, UK., Tapon N; Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, London, UK. nic.tapon@crick.ac.uk.
Jazyk: angličtina
Zdroj: Nature cell biology [Nat Cell Biol] 2023 Apr; Vol. 25 (4), pp. 540-549. Date of Electronic Publication: 2023 Mar 23.
DOI: 10.1038/s41556-023-01110-2
Abstrakt: The epidermis is equipped with specialized mechanosensory organs that enable the detection of tactile stimuli. Here, by examining the differentiation of the tactile bristles, mechanosensory organs decorating the Drosophila adult epidermis, we show that neighbouring epidermal cells are essential for touch perception. Each mechanosensory bristle signals to the surrounding epidermis to co-opt a single epidermal cell, which we named the F-Cell. Once specified, the F-Cell adopts a specialized morphology to ensheath each bristle. Functional assays reveal that adult mechanosensory bristles require association with the epidermal F-Cell for touch sensing. Our findings underscore the importance of resident epidermal cells in the assembly of functional touch-sensitive organs.
(© 2023. The Author(s).)
Databáze: MEDLINE
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