Malignancy rates of salivary gland tumors in Greenlandic Inuit comparable to non-endemic populations; epidemiological mapping of salivary gland tumors 1990-2019.

Autor: Haugaard CF; Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Koege, Denmark., Andreasen S; Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Koege, Denmark., Eriksen PRG; Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Koege, Denmark., Olsen C; Department of Pathology, University Hospital Copenhagen, Copenhagen, Denmark., Kiss K; Department of Pathology, University Hospital Copenhagen, Copenhagen, Denmark., Bjørndal K; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark., Westergaard-Nielsen M; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark., Homøe P; Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Koege, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2023 Mar; Vol. 62 (3), pp. 231-236. Date of Electronic Publication: 2023 Mar 23.
DOI: 10.1080/0284186X.2023.2191337
Abstrakt: Background: Salivary gland tumors are assumed to be predominantly malignant in the Greenlandic Inuit population, but there is limited literature on the subject. We conducted a retrospective cohort study using national registers to describe the histological tumor types, location, incidence, and survival of benign and malignant salivary gland tumors.
Methods: We analyzed data on all Greenlandic Inuit with an epithelial-derived salivary gland tumor from 1990 to 2019. We extracted data from the Central Personal Registry and crossmatched it with the Danish Pathology Data Bank. All specimens were reviewed by a specialized pathologist. We noted patient and histological characteristics, calculated crude and age-adjusted incidence rates, overall survival, and excess mortality.
Results: Our study found that 76% of salivary gland tumors in the Greenlandic Inuit population were benign, with pleomorphic adenoma being the most common. Malignant tumors accounted for 24% of cases, with lymphoepithelial carcinoma being the most common type. The most common place of origin for malignant tumors was the parotid gland (71%) and the submandibular gland (15%). The median age of onset for malignant tumors was 47 years. Age-adjusted incidence rates of malignant tumors for men and women were 3.00 and 4.12 per 100,000 person-years, respectively.
Conclusion: Our findings suggest that the proportion of malignant salivary gland tumors in the Greenlandic Inuit population is similar to other nonendemic populations. Our incidence rates are higher than previously reported, likely due to differences in methodology and definitions of the Inuit population. This study provides valuable insights into the epidemiology of salivary gland tumors in the Greenlandic Inuit population and may have implications for other Inuit populations as well.
Databáze: MEDLINE
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