Impact of age, antiretroviral therapy, and cancer on epigenetic aging in people living with HIV.

Autor: Qing Y; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Chan R; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Fu P; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Cullen J; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Miron A; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Genetics and Genomics, Case Western Reserve University, Cleveland, Ohio, USA., Jacobson JM; Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Pink J; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Gerson SL; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2023 May; Vol. 12 (9), pp. 11010-11019. Date of Electronic Publication: 2023 Mar 23.
DOI: 10.1002/cam4.5809
Abstrakt: Background: Premature aging has been identified as a global risk factor for cancer. Causes of premature aging are multifactorial, including inflammation, infection, chronic stress, and lifestyle factors.
Method: We evaluated whether premature aging in people living with HIV (PLWH) was associated with antiretroviral therapy (ART) or the diagnosis of cancer. We used well-established DNA methylation patterns to assess premature aging, using Horvath et al., in individuals with HIV located in Cleveland, Ohio and compared these to standardized datasets of US historical blood samples. Some of the PLWH developed cancer over time.
Results: We found that DNA methylation analysis identified accelerated aging in PLWH whereas ART therapy mitigated the advancement of DNA methylation age. A variety of cancers were observed in this population, but a cancer diagnosis was not significantly associated with more advanced DNA methylation age.
Conclusion: We find that the age acceleration detected in PLWH is mitigated by ART therapy and is not further accelerated by a diagnosis of cancer.
(© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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