Bacterial invasion of the submicron osteocyte lacuna-canaliculi network (OLCN): a part of osteomyelitis disease biology.
| Autor: | Jensen LK; Department of Veterinary and Animal Science, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Birch JM; Department of Veterinary and Animal Science, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jensen HE; Department of Veterinary and Animal Science, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kirketerp-Møller K; Copenhagen Wound Healing Center, Bispebjerg University Hospital, Copenhagen, Denmark., Gottlieb H; Department of Orthopedic Surgery, Herlev Hospital, Herlev, Denmark. |
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| Jazyk: | angličtina |
| Zdroj: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2023 Jul; Vol. 131 (7), pp. 325-332. Date of Electronic Publication: 2023 May 11. |
| DOI: | 10.1111/apm.13312 |
| Abstrakt: | Two chronic osteomyelitis patients, a diabetic foot osteomyelitis patient and a fracture-related infection patient, all with staphylococci-positive microbiology, were examined to confirm the clinical relevance of bacterial invasion of the submicron osteocyte lacuna-canaliculi network (OLCN) in bone tissue. Based on immunohistochemistry and light microscopy both Staphylococcus aureus and Staphylococcus epidermidis were identified within the OLCN of all four patients. The findings consolidate that bacterial OLCN invasion is a clinically relevant part of osteomyelitis disease biology, which from experimental porcine infections, seems to be time depending. The microscopy pictures of the four patients significantly add to visualize the phenomenon of bacterial OLCN invasion. (© 2023 Scandinavian Societies for Pathology, Medical Microbiology and Immunology.) |
| Databáze: | MEDLINE |
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