Neuronal protein interaction networks in autism spectrum disorder.

Autor:	Bicks LK; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Eyring KW; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Geschwind DH; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, Semel Institue, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Jazyk:	angličtina
Zdroj:	Cell genomics [Cell Genom] 2023 Mar 08; Vol. 3 (3), pp. 100279. Date of Electronic Publication: 2023 Mar 08 (Print Publication: 2023).
DOI:	10.1016/j.xgen.2023.100279
Abstrakt:	How rare protein-disrupting risk variants implicated in autism spectrum disorders (ASDs) interact or functionally converge is unknown. Pintacuda et al. 1 perform proteomics in induced human neurons and identify more than 1,000 interactions, 90% of which were not previously reported, emphasizing the importance of cell-type- and isoform-specific protein interactions in ASD. Competing Interests: The authors declare no competing interests. (© 2023 The Author(s).)
Databáze:	MEDLINE
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