Association of nine pathobionts with periodontitis in four South American and European countries.

Autor:	Àlvarez G; Department of Microbiology, DENTAID Research Center, Cerdanyola del Vallès, Spain., Arredondo A; Department of Microbiology, DENTAID Research Center, Cerdanyola del Vallès, Spain., Isabal S; Department of Microbiology, DENTAID Research Center, Cerdanyola del Vallès, Spain., Teughels W; Department of Oral Health Sciences, KU Leuven, Belgium & Dentistry, University Hospitals Leuven, Leuven, Belgium., Laleman I; Department of Oral Health Sciences, KU Leuven, Belgium & Dentistry, University Hospitals Leuven, Leuven, Belgium., Contreras MJ; School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Isbej L; School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Pharmacology and Toxicology Programme, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Huapaya E; Department of Periodontology, School of Dentistry, Universidad Científica del Sur, Lima, Peru., Mendoza G; Department of Periodontology, School of Dentistry, Universidad Científica del Sur, Lima, Peru.; Department of Periodontics, University of Pennsylvania, School of dental Medicine, Philadelphia, Pennsylvania, USA., Mor C; Department of Periodontology, Universitat Internacional de Catalunya, Barcelona, Spain., Nart J; Department of Periodontology, Universitat Internacional de Catalunya, Barcelona, Spain., Blanc V; Department of Microbiology, DENTAID Research Center, Cerdanyola del Vallès, Spain., León R; Department of Microbiology, DENTAID Research Center, Cerdanyola del Vallès, Spain.
Jazyk:	angličtina
Zdroj:	Journal of oral microbiology [J Oral Microbiol] 2023 Mar 19; Vol. 15 (1), pp. 2188630. Date of Electronic Publication: 2023 Mar 19 (Print Publication: 2023).
DOI:	10.1080/20002297.2023.2188630
Abstrakt:	Aim: Our aim was to compare the prevalence and load of nine pathobionts in subgingival samples of healthy individuals and periodontitis patients from four different countries. Methods: Five hundred and seven subgingival biofilm samples were collected from healthy subjects and periodontitis patients in Belgium, Chile, Peru and Spain. The prevalence and load of Eubacterium brachy, Filifactor alocis, Fretibacterium fastidiosum, Porphyromonas endodontalis, Porphyromonas gingivalis, Selenomonas sputigena, Treponema denticola, Tannerella forsythia and Treponema socranskii were measured by quantitative PCR. Results: The association with periodontitis of all species, except for T. socranskii , was confirmed in all countries but Peru, where only P. endodontalis, P. gingivalis and T. denticola were found to be significantly associated. Moreover, most species showed higher loads at greater CAL and PPD, but not where there was BOP. Through Principal Component Analysis, samples showed clearly different distributions by diagnosis, despite observing a smaller separation in Peruvian samples. Conclusions: Unlike prevalence, relative load was found to be a reliable variable to discriminate the association of the species with periodontitis. Based on this, F. alocis, P. endodontalis, P. gingivalis, T. denticola and T. forsythia may be biomarkers of disease in Belgium, Chile and Spain, due to their significantly higher abundance in periodontitis patients. Competing Interests: The authors declared the following potential conflicts of interest: Dr Nart received research grants through the Universitat Internacional de Catalunya from Klockner Implants and Straumann group; lecture fees from Straumann group, Oral-B and KIN Laboratories; and consultant fees from Klockner Implants. All other authors declared no potential conflicts of interest with respect to the authorship and/or publication of this article. (© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
Databáze:	MEDLINE
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