Parkinson's Disease-Cognitive Rating Scale (PD-CRS): Normative Data and Mild Cognitive Impairment Assessment in Brazil.

Autor: Brandão PRP; Neuroscience and Behavior Laboratory University of Brasília (UnB) Brasília Brazil.; Instituto de Ensino e Pesquisa Hospital Sírio-Libanês Brasília Brazil., Pereira DA; Brazilian Institute of Neuropsychology and Cognitive Sciences (IBNeuro) Brasília Brazil., Grippe TC; Movement Disorders Centre, Toronto Western Hospital - UHN, Division of Neurology University of Toronto Toronto Ontario Canada.; Department of Internal Medicine, Movement Disorders Clinic, Neurology Service Federal University of Minas Gerais (UFMG) Belo Horizonte Brazil., Bispo DDC; Radiology Department Brasilia University Hospital (HUB-UnB) Brasília Brazil.; Hospital Santa Marta Radiology Clinic Taguatinga Brazil., Maluf FB; Hospital Santa Marta Radiology Clinic Taguatinga Brazil., Yunes MP; Brazilian Institute of Neuropsychology and Cognitive Sciences (IBNeuro) Brasília Brazil., Nunes Filho G; Brazilian Institute of Neuropsychology and Cognitive Sciences (IBNeuro) Brasília Brazil., Alves CHL; Federal University of Maranhão, UFMA São Luís Brazil., Pagonabarraga J; Movement Disorders Unit, Neurology Department Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Department of Medicine Barcelona Spain.; Sant Pau Biomedical Research Institute (IIB-Sant Pau) Barcelona Spain.; Centro de Investigación en Red - Enfermedades Neurodegenerativas (CIBERNED) Spain., Kulisevsky J; Movement Disorders Unit, Neurology Department Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Department of Medicine Barcelona Spain.; Sant Pau Biomedical Research Institute (IIB-Sant Pau) Barcelona Spain.; Centro de Investigación en Red - Enfermedades Neurodegenerativas (CIBERNED) Spain., da Costa AML; Neuroscience and Behavior Laboratory University of Brasília (UnB) Brasília Brazil., Serafim CFDV; Neuroscience and Behavior Laboratory University of Brasília (UnB) Brasília Brazil., Ferreira ACDB; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., Bastos AMM; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., Belchior ACF; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., de Almeida BLC; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., de Almeida E Castro BM; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., Matos MS; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., de Matos RC; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., Rios GA; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., Carneiro LO; Medical School Federal University of Goiás (UFG) Goiânia Brazil., da Mota BCC; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., Castro LEDR; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., Rocha VLS; Medical School Centro Universitário de Brasília (UniCEUB) Brasília Brazil., Tavares MCH; Neuroscience and Behavior Laboratory University of Brasília (UnB) Brasília Brazil., Cardoso F; Department of Internal Medicine, Movement Disorders Clinic, Neurology Service Federal University of Minas Gerais (UFMG) Belo Horizonte Brazil.
Jazyk: angličtina
Zdroj: Movement disorders clinical practice [Mov Disord Clin Pract] 2023 Feb 25; Vol. 10 (3), pp. 452-465. Date of Electronic Publication: 2023 Feb 25 (Print Publication: 2023).
DOI: 10.1002/mdc3.13657
Abstrakt: Background: The Parkinson's Disease-Cognitive Rating Scale (PD-CRS) assesses posterior-cortical and frontal-subcortical cognitive functioning and distinguishes mild cognitive impairment in Parkinson's disease (PD-MCI); however, it was not evaluated in Brazil.
Objectives: To investigate PD-CRS's reliability, validity, normative data, and accuracy for PD-MCI screening in Brazil.
Methods: The effects of age, education, and sex on PD-CRS scores were explored. The instrument was tested in 714 individuals (53% female, 21-94 years), with a broad range of education and no neurodegenerative disorder. Trail Making, Consonant Trigrams, Five-Point, and semantic fluency tests were administered for comparison. A second study enrolled patients with PD and intact cognition (n = 44, 59.75 ± 10.79 years) and with PD-MCI (n = 25, 65.76 ± 10.33 years) to investigate criterion validity. PD-CRS subtests were compared with the Cambridge Automated Neuropsychological Battery memory and executive tasks.
Results: PD-CRS was unidimensional and reliable (McDonald's ω = 0.83). Using robust multiple regressions, age, and education predicted the total and derived scores in the normative sample. At the 85-point cutoff, PD-MCI was detected with 68% sensitivity and 86% specificity (area under the curve = 0.870). PD-CRS scores strongly correlated with executive and verbal/visual memory tests in both normative and clinical samples.
Conclusions: This study investigated the applicability of PD-CRS in the Brazilian context. The scale seems helpful in screening for PD-MCI, with adequate internal consistency and construct validity. The PD-CRS variance is influenced by age and educational level, a critical issue for cognitive testing in countries with educational and cultural heterogeneity.
(© 2023 International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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