Proteins in urine - Possible biomarkers of endometriosis.

Autor: Višnić A; Clinical Hospital Center Rijeka, Clinic for Gynecology and Obstetrics, Rijeka, Croatia., Čanadi Jurešić G; Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University in Rijeka, Rijeka, Croatia. Electronic address: gordanacj@medri.uniri.hr., Domitrović R; Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University in Rijeka, Rijeka, Croatia., Klarić M; Clinical Hospital Center Rijeka, Clinic for Gynecology and Obstetrics, Rijeka, Croatia., Šepić TS; Clinical Hospital Center Rijeka, Clinic for Gynecology and Obstetrics, Rijeka, Croatia., Barišić D; Special Hospital Radiochirurgia, Zagreb, Croatia.
Jazyk: angličtina
Zdroj: Journal of reproductive immunology [J Reprod Immunol] 2023 Jun; Vol. 157, pp. 103941. Date of Electronic Publication: 2023 Mar 17.
DOI: 10.1016/j.jri.2023.103941
Abstrakt: In the pathogenesis of endometriosis, a number of pathological reactions occur. Proteins secreted in the urine are thought to interact with each other and stimulate the pathological processes in endometriosis. Identifying one or more proteins that are specific enough and could serve as biomarkers for endometriosis is both a challenge and a necessity that would facilitate diagnosis. The urine of patients treated in a tertiary university hospital between July 1, 2020 and June 30, 2021 was analyzed. The studied group consists of patients who were treated surgically for endometriosis and in whom the diagnosis was confirmed by pathohistological analysis. The control group consists of patients who were operated for functional ovarian cysts. Urinary proteins were analyzed by chromatography and mass spectrometry (LC-MS/MS). We identified 17 proteins in urine whose concentrations were statistically significantly different in the group with endometriosis (N = 16) compared with the control groups (N = 16). The detected proteins were classified into groups according to their function in invasion, migration and proliferation, proteolysis, immune system, cell adhesion and vascular system. For all mentioned proteins the difference in concentration is statistically significant p < 0.005. Proteins are secreted in the urine of patients with endometriosis that may be involved in the pathogenesis of the disease and are possible biomarkers for endometriosis.
Competing Interests: Conflicts of interest The authors declare that they have no competing interests.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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