| Autor: |
Barcelos FF; Universidade Vila Velha, Programa de Pós-graduação em Biotecnologia Vegetal, Rua José Dantas de Melo, 21, Boa Vista, 29102-770 Vila Velha, ES, Brazil., Alves TA; Universidade Federal do Espírito Santo, Departamento de Biologia, Alto Universitário, s/n, Guararema, 29500-000 Alegre, ES, Brazil., Gazolla PAR; Universidade Federal de Viçosa, Departamento de Química, Av. P.H. Rolfs, s/n, 36570-900 Viçosa, MG, Brazil., Teixeira RR; Universidade Federal de Viçosa, Departamento de Química, Av. P.H. Rolfs, s/n, 36570-900 Viçosa, MG, Brazil., Queiroz VT; Universidade Federal do Espírito Santo, Departamento de Química e Física, Alto Universitário, s/n, Guararema, 29500-000 Alegre, ES, Brazil., Praça-Fontes MM; Universidade Federal do Espírito Santo, Departamento de Biologia, Alto Universitário, s/n, Guararema, 29500-000 Alegre, ES, Brazil., Morais PAB; Universidade Federal do Espírito Santo, Departamento de Química e Física, Alto Universitário, s/n, Guararema, 29500-000 Alegre, ES, Brazil., Fonseca VR; Universidade Federal do Espírito Santo, Laboratório de Petroleômica e Forense, Departamento de Química, Av. Fernando Ferrari, 514, 29075-910 Vitória, ES, Brazil., Romão W; Universidade Federal do Espírito Santo, Laboratório de Petroleômica e Forense, Departamento de Química, Av. Fernando Ferrari, 514, 29075-910 Vitória, ES, Brazil., Lacerda Júnior V; Universidade Federal do Espírito Santo, Laboratório de Petroleômica e Forense, Departamento de Química, Av. Fernando Ferrari, 514, 29075-910 Vitória, ES, Brazil., Scherer R; Universidade Vila Velha, Programa de Pós-graduação em Ciências Farmacêuticas, Rua José Dantas de Melo, 21, Boa Vista, 29102-770 Vila Velha, ES, Brazil., Costa AV; Universidade Federal do Espírito Santo, Departamento de Química e Física, Alto Universitário, s/n, Guararema, 29500-000 Alegre, ES, Brazil. |
| Abstrakt: |
The control of weeds in agriculture is mainly conducted with the use of synthetic herbicides. However, environmental and human health concerns and increased resistance of weeds to existing herbicides have increased the pressure on researchers to find new active ingredients for weed control which present low toxicity to non-target organisms, are environmentally safe, and can be applied at low concentrations. It is herein described the synthesis of glycerol-fluorinated triazole derivatives and evaluation of their phytotoxic and cytogenotoxic activities. Starting from glycerol, ten fluorinated triazole derivatives were prepared in four steps. The assessment of them on Lactuca sativa revealed that they present effects on phytotoxic and cytogenotoxic parameters with different degrees of efficiency. The compounds 4a, 4b, 4d, 4e, 4i, and 4j have pre-emergent inhibition behavior, while all the investigated compounds showed post emergent effect. Mechanism of action as clastogenic, aneugenic, and epigenetic were observed in the lettuce root meristematic cells, with alterations as stick chromosome, bridge, delay, c-metaphase, and loss. It is believed that glycerol-fluorinated triazole derivatives possess a scaffold that can be explored towards the development of new chemicals for the control of weed species. |
