Memory for Semantically Related Objects Differentiates Cognitively Unimpaired Autosomal Dominant Mutation Carriers from Non-Carrier Family Members.

Autor: Fox-Fuller JT; Yakeel T. Quiroz, PhD, Associate Professor, Harvard Medical School, Departments of Psychiatry and Neurology, Massachusetts General Hospital Building #39 1st Ave., Suite #101, Charlestown, MA 02129, USA, Phone (617) 643-5944; Fax: (617) 726-5760; E-mail: yquiroz@mgh.harvard.edu., Martinez JE, Baena A, Londono N, Munera D, Noriega D, Vila-Castelar C, Aduen PA, Lopera F, Cronin-Golomb A, Quiroz YT
Jazyk: angličtina
Zdroj: The journal of prevention of Alzheimer's disease [J Prev Alzheimers Dis] 2023; Vol. 10 (2), pp. 322-327.
DOI: 10.14283/jpad.2023.14
Abstrakt: Early cognitive changes due to Alzheimer's disease (AD) include difficulties in semantic access and working memory. Using a computerized cognitive test developed by our group, called the Memory for Semantically Related Objects test (MESERO), we evaluated if cognitively unimpaired carriers of an autosomal dominant AD (ADAD) mutation performed worse on this test than non-carrier family members. 35 cognitively unimpaired ADAD mutation carriers and 26 non-carrier family members from a Colombian ADAD cohort took the MESERO on a laptop computer. Cognitively unimpaired ADAD carriers had significantly worse MESERO total scores than non-carrier family members, driven by worse performance in semantically-related object sets; group performances did not differ on semantically unrelated object sets. Findings suggest that MESERO performance may be sensitive to subtle cognitive changes associated with AD. Future MESERO research should examine performances between healthy older adults and people at risk for sporadic AD.
Competing Interests: Y.T.Q has served as consultant for Biogen. The other co-authors declare no competing interests.
Databáze: MEDLINE
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