Relationships between T-lymphocytes and physical function in adults with chronic lymphocytic leukemia: Results from the HEALTH4CLL pilot study.

Autor: Crane JC; Department of Health and Human Performance, University of Houston, Houston, Texas, USA., Gordon MJ; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Basen-Engquist K; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Department of Behavioral Science, Division of Cancer Prevention and Population Services, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Center for Energy Balance in Cancer Prevention and Survivorship, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Department of Health Promotion and Behavioral Sciences, The University of Texas School of Public Health, Houston, Texas, USA.; Department of Kinesiology, Rice University, Houston, Texas, USA., Ferrajoli A; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Markofski MM; Department of Health and Human Performance, University of Houston, Houston, Texas, USA., Lee CY; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Department of Behavioral Science, Division of Cancer Prevention and Population Services, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Fares S; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Department of Behavioral Science, Division of Cancer Prevention and Population Services, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Simpson RJ; School of Nutritional Sciences and Wellness, The University of Arizona, Tucson, Arizona, USA.; Department of Pediatrics, The University of Arizona, Tucson, Arizona, USA.; Department of Immunobiology, The University of Arizona, Tucson, Arizona, USA.; The University of Arizona Cancer Center, Tucson, Arizona, USA., LaVoy EC; Department of Health and Human Performance, University of Houston, Houston, Texas, USA.
Jazyk: angličtina
Zdroj: European journal of haematology [Eur J Haematol] 2023 Jun; Vol. 110 (6), pp. 732-742. Date of Electronic Publication: 2023 Mar 31.
DOI: 10.1111/ejh.13958
Abstrakt: Objective: Examine physical function and T-cell phenotype in patients with chronic lymphocytic leukemia (CLL) before and after a physical activity (PA) intervention.
Methods: Physical function measures and blood samples were collected from CLL patients (Rai stage 0-4, 50% receiving targeted therapy, N = 24) enrolled in a 16-week intervention of at-home aerobic and/or resistance exercise. Flow cytometry characterized T-cells in cryopreserved peripheral blood cells. Wilcoxon signed-rank test compared physical function and T-cell phenotype at baseline and 16-weeks; Kendall's Tau assessed associations between variables.
Results: Godin leisure-time PA score increased from baseline to 16-weeks (mean difference: 14.61, p < .01) and fatigue decreased (mean difference: 6.71, p < .001). At baseline, lower fatigue correlated with a lower proportion of CD8+ T-cells (τ = 0.32, p = .03) and cardiorespiratory fitness (CRF) inversely correlated with the percentage of PD-1+CD8+ T-cells (τ -0.31, p = .03). At 16-weeks, CRF inversely correlated with the proportion of PD-1+CD4+ T-cells (τ -0.34, p = .02). Reduced fatigue at 16-weeks correlated with an increased CD4:CD8 ratio (τ = 0.36, p = .02) and lower percentage of HLA-DR+PD-1+CD4+ T-cells (τ = -0.37, p = .01).
Conclusions: This intervention increased leisure-time PA and decreased fatigue in CLL patients. These changes correlated with an increased CD4:CD8 T-cell ratio and reduced proportion of T-cells subsets previously associated with poor outcomes in CLL patients.
Trial Registration: ClinicalTrials.gov Identifier: NCT02194387.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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