Association of SARS-CoV-2 Infection with Neurological Symptoms and Neuroimaging Manifestations in the Pediatric Population: A Systematic Review.

Autor:	Kwan ATH; University of Ottawa., Al-Kassimi K; American University in the Emirates., Portnoff JS; The University of Queensland., Tesla M; University of Toronto., Hanafimosalman M; McGill University., Gharibi N; Saint James School of Medicine., Ni T; University of Toronto., Sonfack DJN; Laval University., Martyniuk J; University of Toronto., Arfaie S; McGill University., Mashayekhi MS; University of British Columbia., Mofatteh M; Queen's University Belfast., Jeremian R; McGill University., Moscote-Salazar LR; University of Cartagena., Lee Á; Hospital Ángeles del Pedregal., Jawad MY; Brain and Cognition Discovery Foundation., Guo Z; Brain and Cognition Discovery Foundation., Ceban F; Brain and Cognition Discovery Foundation., Teopiz KM; Brain and Cognition Discovery Foundation., Mansur RB; University of Toronto., Ho R; Yong Loo Lin School of Medicine., Rosenblat JD; University of Toronto., Cao B; Southwest University., Rhee TG; Yale University., McIntyre RS; University of Toronto.
Jazyk:	angličtina
Zdroj:	Research square [Res Sq] 2023 Mar 09. Date of Electronic Publication: 2023 Mar 09.
DOI:	10.21203/rs.3.rs-2653722/v1
Abstrakt:	Background: Neurological manifestations have been widely reported in adults with COVID-19, yet the extent of involvement among the pediatric population is currently poorly characterized. The objective of our systematic review is to evaluate the association of SARS-CoV-2 infection with neurological symptoms and neuroimaging manifestations in the pediatric population. Methods: A literature search of Cochrane Library; EBSCO CINAHL; Global Index Medicus; OVID AMED, Embase, Medline, PsychINFO; and Scopus was conducted in accordance with the Peer Review of Electronic Search Strategies form (October 1, 2019 to March 15, 2022). Studies were included if they reported (1) COVID-19-associated neurological symptoms and neuroimaging manifestations in individuals aged < 18 years with a confirmed, first SARS-CoV-2 infection and were (2) peer-reviewed. Full-text reviews of 222 retrieved articles were performed, along with subsequent reference searches. Results: A total of 843 nonduplicate records were retrieved. Of the 19 identified studies, there were ten retrospective observational studies, seven case series, one case report, and one prospective cohort study. A total of 6,985 individuals were included, where 12.8% of hospitalized patients experienced neurocognitive impairments: MIS-C (24.2%), neuroinflammation (10.1%), and encephalopathy (8.1%) were the most common disorders; headaches (16.8%) and seizures (3.8%) were the most common symptoms. Based on pediatric-specific cohorts, children experienced more drowsiness (7.3% vs. 1.3%) and muscle weakness (7.3% vs. 6.3%) as opposed to adolescents. Agitation or irritability was observed more in children (7.3%) than infants (1.3%). Conclusion: Our findings revealed a high prevalence of immune-mediated patterns of disease among COVID-19 positive pediatric patients with neurocognitive abnormalities. Competing Interests: Competing interests: The authors declare no competing interests.
Databáze:	MEDLINE
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