Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.

Autor:	Hollunder B; Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany., Ostrem JL; Movement Disorders and Neuromodulation Centre, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Sahin IA; Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany., Rajamani N; Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Oxenford S; Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Butenko K; Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Neudorfer C; Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Reinhardt P; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany., Zvarova P; Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany., Polosan M; Univ. Grenoble Alpes, Grenoble, France.; Inserm, U1216, Grenoble Institut des Neurosciences, Grenoble, France.; Psychiatry Department, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France., Akram H; Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, UK.; National Hospital for Neurology and Neurosurgery, University College London Queen Square Institute of Neurology, London, UK., Vissani M; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.; Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy., Zhang C; Department of Neurosurgery, Rujin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Sun B; Department of Neurosurgery, Rujin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Navratil P; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Reich MM; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Volkmann J; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Yeh FC; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Baldermann JC; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Dembek TA; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Visser-Vandewalle V; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Alho EJL; Clinic of Pain and Functional Neurosurgery, São Paulo, Brazil., Franceschini PR; Department of Neurology and Neurosurgery, University of Caxias do Sul, Rio Grande do Sul, Brazil., Nanda P; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Finke C; Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany., Kühn AA; Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany.; NeuroCure Cluster of Excellence, Charité - Universitätsmedizin Berlin, Berlin, Germany., Dougherty DD; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Richardson RM; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Bergman H; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.; Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, The Hebrew University, Hassadah Medical School, Jerusalem, Israel.; Department of Neurosurgery, Hadassah Medical Center, Jerusalem, Israel., DeLong MR; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Mazzoni A; The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.; Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy., Romito LM; Parkinson and Movement Disorders Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Tyagi H; Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, UK.; National Hospital for Neurology and Neurosurgery, University College London Queen Square Institute of Neurology, London, UK., Zrinzo L; Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, UK.; National Hospital for Neurology and Neurosurgery, University College London Queen Square Institute of Neurology, London, UK., Joyce EM; Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, UK.; National Hospital for Neurology and Neurosurgery, University College London Queen Square Institute of Neurology, London, UK., Chabardes S; Univ. Grenoble Alpes, Grenoble, France.; Inserm, U1216, Grenoble Institut des Neurosciences, Grenoble, France.; Department of Neurosurgery, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France., Starr PA; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA., Li N; Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Horn A; Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2023 Aug 25. Date of Electronic Publication: 2023 Aug 25.
DOI:	10.1101/2023.03.07.23286766
Abstrakt:	Frontal circuits play a critical role in motor, cognitive, and affective processing - and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)function remains largely elusive. Here, we study 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregate the frontal cortex into circuits that became dysfunctional in each of them. Dysfunctional circuits were topographically arranged from occipital to rostral, ranging from interconnections with sensorimotor cortices in dystonia, with the primary motor cortex in Tourette's syndrome, the supplementary motor area in Parkinson's disease, to ventromedial prefrontal and anterior cingulate cortices in obsessive-compulsive disorder. Our findings highlight the integration of deep brain stimulation with brain connectomics as a powerful tool to explore couplings between brain structure and functional impairment in the human brain. Competing Interests: Declaration of Competing Interests J.L.O. reports research grant support from Medtronic and Boston Scientific and is a consultant for Abbott, outside of the submitted work. M.M.R. reports grant support and honoraria for speaking from Medtronic and Boston Scientific, outside of the submitted work. J.V. reports grants and personal fees from Medtronic Inc., grants, and personal fees from Boston Scientific, personal fees from Abbott, outside of the submitted work. H.B. is consultant of Alpha-Omega, outside of the submitted work. S.C. is consultant for Medtronic and Boston Scientific, outside of the submitted work. A.H. is a consultant for FxNeuromodulation and Abbott, and reports lecture fees from Boston Scientific, outside of the submitted work. B.H., I.A.S., N.R., S.O., K.B., C.N., P.R., P.Z., M.P., H.A., M.V., C.Z., B.S., P.N., F.-C.Y., J.C.B., T.A.D., V.V.-V., E.J.L.A., P.R.F., C.F., A.A.K., P.N., D.D.D., R.M.R., M.R.D., A.M., L.M.R., H.T., L.Z., E.M.J., P.A.S., and N.L. report no competing interests.
Databáze:	MEDLINE
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