Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs is Associated with Hyperuricemia in Females with Polycystic Ovarian Syndrome.

Autor: Li X; Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China., Wu W; Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China., Li X; Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China., Wu H; Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China., Wang X; Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China., Tian W; Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China. tianwenyan1108@163.com., Zhang H; Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China. huiying_zhang2020@126.com.
Jazyk: angličtina
Zdroj: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2023 Sep; Vol. 30 (9), pp. 2758-2766. Date of Electronic Publication: 2023 Mar 21.
DOI: 10.1007/s43032-023-01214-y
Abstrakt: This study is aimed at evaluating the correlation between the skeletal muscle mass index (SMI) of different body parts and hyperuricemia in females with polycystic ovary syndrome (PCOS), thus, providing scientific guidance on lifestyle self-management for patients with PCOS. The cross-sectional study included 171 patients with PCOS, which were divided into two distinct sub-groups based on the presence or absence of hyperuricemia. Anthropometric and serological characteristics of the population with PCOS focusing on skeletal muscle mass were conducted. PCOS patients with hyperuricemia had significantly greater SMI in different body parts. Further binary logistic regression analysis revealed that SMI of the bilateral lower limbs was positively associated with hyperuricemia with an adjusted odds ratio (95% confidence interval) of 1.235 (1.103 - 1.384), p < 0.001. The optimal cut-off value of SMI of the bilateral lower limbs in predicting hyperuricemia was 5.11 (Youden index = 0.490). Combined with the mean value of SMI in the bilateral upper limbs, the safe range of SMI of the bilateral lower limbs in patients with PCOS was calculated as 3.64 - 5.11, with the sensitivity and negative predictive values being 83.9% and 65.1%, respectively. Excessively increased SMI of the bilateral lower limbs was correlated with hyperuricemia in patients with PCOS.
(© 2023. The Author(s), under exclusive licence to Society for Reproductive Investigation.)
Databáze: MEDLINE
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