| Autor: |
Koller K; Department of Ophthalmology and Vision Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil., Matos Teixeira Fonseca K; Department of Ophthalmology and Vision Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil., Areco KN; Health Informatics Department, Federal University of São Paulo (UNIFESP), São Paulo, Brazil., Fernández-Zamora Y; Department of Ophthalmology and Vision Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil., Silva LMP; Department of Ophthalmology and Vision Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil., Casaroli-Marano RP; Department of Ophthalmology and Vision Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.; Department of Surgery and Hospital Clinic of Barcelona, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Coimbra CG; Laboratory of Neuroprotection and Neuropathology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil., Muccioli C; Department of Ophthalmology and Vision Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. |
| Abstrakt: |
This study investigated the correlation between serum vitamin D levels and intraocular inflammation in patients with autoimmune uveitis (AIU). We evaluated 67 patients with active and inactive AIU and measured their serum 25-hydroxyvitamin D [25(OH)D] concentration, sun exposure habits, number of relapses, and complications. Of the patients evaluated, 85% had significantly lower vitamin D levels, and patients with active uveitis had lower 25(OH)D levels than those with inactive uveitis. The odds of developing active uveitis decreased by 6% with each 1-unit increase in 25(OH)D. Patients with recurrent active AIU had significantly lower 25(OH)D serum levels than inactive forms, indicating that low vitamin D levels may alter the clinical course of intraocular inflammation in AIU. Additionally, the study found that a higher mean BMI increased the chances of an individual having active uveitis by 14%. These results suggest that serum vitamin D concentration could be a prognostic clinical biomarker in AIU. |
