Physical Function and Physical Activity in Older Breast Cancer Survivors: 5-Year Follow-Up from the Climb Every Mountain Study.

Autor:	Lemij AA; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Liefers GJ; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Derks MGM; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands., Bastiaannet E; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Fiocco M; Mathematical Institute, Leiden University and Department of Biomedical Data Science, Section Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands., Lans TE; Department of Surgery, Admiraal de Ruyter Hospital, Goes, The Netherlands., van der Pol CC; Department of Surgery, Alrijne Hospital, Leiden and Leiderdorp, The Netherlands., Vulink AJE; Department of Medical Oncology, Reinier de Graaf Gasthuis, Delft, The Netherlands., van Gerven L; Department of Internal Medicine, LangeLand Hospital, Zoetermeer, The Netherlands., Guicherit OR; Department of Surgery, Haaglanden Medical Center, The Hague, The Netherlands., Linthorst-Niers EMH; Department of Surgery, Groene Hart Hospital, Gouda, The Netherlands., Merkus JWS; Department of Surgery, Haga Hospital, The Hague, The Netherlands., van Dalen T; Department of Surgery, Diakonessenhuis, Utrecht, The Netherlands., Portielje JEA; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands., de Glas NA; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk:	angličtina
Zdroj:	The oncologist [Oncologist] 2023 Jun 02; Vol. 28 (6), pp. e317-e323.
DOI:	10.1093/oncolo/oyad027
Abstrakt:	Background: A decline in physical activity and the ability to perform activities of daily living (ADL) and instrumental activities of daily living (IADL) could interfere with independent living and quality of life in older patients, but may be prevented with tailored interventions. The aim of the current study was to assess changes in physical activity and ADL/IADL in the first 5 years after breast cancer diagnosis in a real-world cohort of older patients and to identify factors associated with physical decline. Methods: Patients aged ≥70 years with in situ or stages I-III breast cancer were included in the prospective Climb Every Mountain cohort study. Linear mixed models were used to assess physical activity (according to Metabolic Equivalent of Task (MET) hours per week) and ADL/IADL (according to the Groningen Activity Restriction Scale (GARS)) over time. Secondly, the association with geriatric characteristics, treatment, quality of life, depression, apathy, and loneliness was analyzed. Results: A total of 239 patients were included. Physical activity and ADL/IADL changed in the first 5 years after diagnosis (mean change from baseline -11.6 and +4.2, respectively). Geriatric characteristics at baseline were strongly associated with longitudinal change in physical activity and ADL/IADL, whereas breast cancer treatment was not. A better quality of life was associated with better physical activity and preservation of ADL/IADL, while depression and loneliness were negatively associated with these outcomes. Discussion: Geriatric characteristics, loneliness, and depressive symptoms were associated with physical decline in older patients with breast cancer, while breast cancer treatment was not. (© The Author(s) 2023. Published by Oxford University Press.)
Databáze:	MEDLINE
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