The gut microbiome in social anxiety disorder: evidence of altered composition and function.

Autor: Butler MI; Department of Psychiatry & Neurobehavioral Science, University College Cork, Cork, Ireland. marybutler1910@gmail.com.; APC Microbiome Ireland, University College Cork, Cork, Ireland. marybutler1910@gmail.com., Bastiaanssen TFS; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Long-Smith C; APC Microbiome Ireland, University College Cork, Cork, Ireland., Morkl S; Department of Psychiatry & Neurobehavioral Science, University College Cork, Cork, Ireland.; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria., Berding K; APC Microbiome Ireland, University College Cork, Cork, Ireland., Ritz NL; APC Microbiome Ireland, University College Cork, Cork, Ireland., Strain C; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Teagasc Food Research Programme, Moorepark, Fermoy, Co, Cork, T12 YN60, Ireland., Patangia D; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Teagasc Food Research Programme, Moorepark, Fermoy, Co, Cork, T12 YN60, Ireland., Patel S; APC Microbiome Ireland, University College Cork, Cork, Ireland.; School of Microbiology, University College Cork, Cork, Ireland., Stanton C; APC Microbiome Ireland, University College Cork, Cork, Ireland.; School of Microbiology, University College Cork, Cork, Ireland., O'Mahony SM; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Cryan JF; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Clarke G; Department of Psychiatry & Neurobehavioral Science, University College Cork, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland., Dinan TG; Department of Psychiatry & Neurobehavioral Science, University College Cork, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2023 Mar 20; Vol. 13 (1), pp. 95. Date of Electronic Publication: 2023 Mar 20.
DOI: 10.1038/s41398-023-02325-5
Abstrakt: The microbiome-gut-brain axis plays a role in anxiety, the stress response and social development, and is of growing interest in neuropsychiatric conditions. The gut microbiota shows compositional alterations in a variety of psychiatric disorders including depression, generalised anxiety disorder (GAD), autism spectrum disorder (ASD) and schizophrenia but studies investigating the gut microbiome in social anxiety disorder (SAD) are very limited. Using whole-genome shotgun analysis of 49 faecal samples (31 cases and 18 sex- and age-matched controls), we analysed compositional and functional differences in the gut microbiome of patients with SAD in comparison to healthy controls. Overall microbiota composition, as measured by beta-diversity, was found to be different between the SAD and control groups and several taxonomic differences were seen at a genus- and species-level. The relative abundance of the genera Anaeromassillibacillus and Gordonibacter were elevated in SAD, while Parasuterella was enriched in healthy controls. At a species-level, Anaeromassilibacillus sp An250 was found to be more abundant in SAD patients while Parasutterella excrementihominis was higher in controls. No differences were seen in alpha diversity. In relation to functional differences, the gut metabolic module 'aspartate degradation I' was elevated in SAD patients. In conclusion, the gut microbiome of patients with SAD differs in composition and function to that of healthy controls. Larger, longitudinal studies are warranted to validate these preliminary results and explore the clinical implications of these microbiome changes.
(© 2023. The Author(s).)
Databáze: MEDLINE
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