C-reactive protein partially mediates the inverse association between coffee consumption and risk of type 2 diabetes: The UK Biobank and the Rotterdam study cohorts.

Autor: Ochoa-Rosales C; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile. Electronic address: carolina.ochoa@uai.cl., van der Schaft N; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands. Electronic address: n.vanderschaft@erasmusmc.nl., Braun KVE; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Nutrition and Dietetics, Faculty of Health, Nutrition and Sport, The Hague University of Applied Sciences, the Netherlands. Electronic address: k.braun@erasmusmc.nl., Ho FK; School of Health and Wellbeing, University of Glasgow, Glasgow, UK. Electronic address: Frederick.Ho@glasgow.ac.uk., Petermann-Rocha F; School of Health and Wellbeing, University of Glasgow, Glasgow, UK; Centro de Investigación Biomédica, Facultad de Medicina, Universidad Diego Portales, Santiago, Chile. Electronic address: fanny.petermann@udp.cl., Ahmadizar F; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Data Science and Biostatistics, University Medical Center Utrecht, Utrecht, Netherlands. Electronic address: F.Ahmadizar@umcutrecht.nl., Kavousi M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands. Electronic address: m.kavousi@erasmusmc.nl., Pell JP; School of Health and Wellbeing, University of Glasgow, Glasgow, UK. Electronic address: Jill.Pell@glasgow.ac.uk., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands. Electronic address: m.a.ikram@erasmusmc.nl., Celis-Morales CA; School of Health and Wellbeing, University of Glasgow, Glasgow, UK; British Heart Foundation Glasgow Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health Sciences, University of Glasgow, Glasgow, UK; Research Centre on Exercise Physiology (CIFE), Universidad Mayor, Santiago, Chile; Research Group in Education, Physical Activity and Health (GEEAFyS), Universidad Católica del Maule, Talca, Chile. Electronic address: Carlos.Celis@glasgow.ac.uk., Voortman T; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands. Electronic address: Trudy.voortman@erasmusmc.nl.
Jazyk: angličtina
Zdroj: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2023 May; Vol. 42 (5), pp. 661-669. Date of Electronic Publication: 2023 Mar 07.
DOI: 10.1016/j.clnu.2023.02.024
Abstrakt: Background: Coffee is among the most consumed beverages worldwide. Coffee consumption has been associated with lower risk of type 2 diabetes mellitus (T2D), but underlying mechanisms are not well understood. We aimed to study the role of classic and novel-T2D biomarkers with anti- or pro-inflammatory activity in the association between habitual coffee intake and T2D risk. Furthermore, we studied differences by coffee types and smoking status in this association.
Methods: Using two large population-based cohorts, the UK-Biobank (UKB; n = 145,368) and the Rotterdam Study (RS; n = 7111), we investigated associations of habitual coffee consumption with incident T2D and repeated measures of insulin resistance (HOMA-IR), using Cox proportional hazards and mixed effect models, respectively. Additionally, we studied associations between coffee and subclinical inflammation biomarkers including C-reactive protein (CRP) and IL-13, and adipokines, such as adiponectin and leptin, using linear regression models. Next, we performed formal causal mediation analyses to investigate the role of coffee-associated biomarkers in the association of coffee with T2D. Finally, we evaluated effect modification by coffee type and smoking. All models were adjusted for sociodemographic, lifestyle and health-related factors.
Results: During a median follow-up of 13.9 (RS) and 7.4 (UKB) years, 843 and 2290 incident T2D cases occurred, respectively. A 1 cup/day increase in coffee consumption was associated with 4% lower T2D risk (RS, HR = 0.96 [95%CI 0.92; 0.99], p = 0.045; UKB, HR = 0.96 [0.94; 0.98], p < 0.001), with lower HOMA-IR (RS, log-transformed β = -0.017 [-0.024;-0.010], p < 0.001), and with lower CRP (RS, log-transformed β = -0.014 [-0.022;-0.005], p = 0.002; UKB, β = -0.011 [-0.012;-0.009], p < 0.001). We also observed associations of higher coffee consumption with higher serum adiponectin and IL-13 concentrations, and with lower leptin concentrations. Coffee-related CRP levels partially mediated the inverse association of coffee intake with T2D incidence (average mediation effect RS β = 0.105 (0.014; 0.240), p = 0.016; UKB β = 6.484 (4.265; 9.339), p < 0.001), with a proportion mediated by CRP from 3.7% [-0.012%; 24.4%] (RS) to 9.8% [5,7%; 25.8%] (UKB). No mediation effect was observed for the other biomarkers. Coffee-T2D and coffee-CRP associations were generally stronger among consumers of ground (filtered or espresso) coffee and among never and former smokers.
Conclusions: Lower subclinical inflammation may partially mediate the beneficial association between coffee consumption and lower T2D risk. Consumers of ground coffee and non-smokers may benefit the most. KEYWORDS (MESH TERMS): coffee consumptions; diabetes mellitus, type 2; inflammation; adipokines; biomarkers; mediation analysis; follow-up studies.
Competing Interests: Conflict of Interest The authors declare no conflict of interest.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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