Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations.

Autor: Kaplan H; Economic Science Institute, Chapman University, Orange, CA 82866., Hooper PL; Economic Science Institute, Chapman University, Orange, CA 82866.; Department of Anthropology, University of New Mexico, Albuquerque, NM 87131., Gatz M; Center for Economic and Social Research, University of Southern California, Los Angeles, CA 90089., Mack WJ; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089., Law EM; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.; Department of Radiology, The Alfred Health Hospital, Melbourne, VIC 3004, Australia.; iBRAIN Research Laboratory, Departments of Neuroscience, Computer Systems and Electrical Engineering, Monash University, Melbourne, VIC 3800, Australia., Chui HC; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.; Alzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089., Sutherland ML; MemorialCare Health Systems, Fountain Valley, CA 92708., Sutherland JD; MemorialCare Health Systems, Fountain Valley, CA 92708., Rowan CJ; Renown Institute for Heart and Vascular Health, Reno, NV 89502.; School of Medicine, University of Nevada, Reno, NV 89557., Wann LS; Division of Cardiology, University of New Mexico, Albuquerque, NM 87131., Allam AH; Department of Cardiology, School of Medicine, Al-Azhar University, Al Mikhaym Al Daem, Cairo 4334003, Egypt., Thompson RC; Saint Luke's Mid America Heart Institute, University of Missouri - Kansas City, Kansas City, MO 64111., Michalik DE; Department of Pediatrics, School of Medicine, University of California at Irvine, Orange, CA 92617.; MemorialCare Miller Children's and Women's Hospital, Long Beach, CA 90806., Lombardi G; Laboratorio de Paleopatologia, Catedra Pedro Weiss, Universidad Peruana Cayetano Heredia, Lima 15102, Peru., Miyamoto MI; Providence Mission Hospital, Mission Viejo, CA 92691., Eid Rodriguez D; Institute of Biomedical Research, San Simon University, Cochabamba, Bolivia., Copajira Adrian J; Tsimane Health and Life History Project, San Borja, Beni, Bolivia., Quispe Gutierrez R; Tsimane Health and Life History Project, San Borja, Beni, Bolivia., Beheim BA; Department of Human Behavior, Ecology and Culture, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany., Cummings DK; Economic Science Institute, Chapman University, Orange, CA 82866., Seabright E; Department of Anthropology, University of New Mexico, Albuquerque, NM 87131.; School of Collective Intelligence, Universite Mohammed 6 Polytechnic, Ben Guerir 43150, Morocco., Alami S; School of Collective Intelligence, Universite Mohammed 6 Polytechnic, Ben Guerir 43150, Morocco.; Department of Anthropology, University of California Santa Barbara, Santa Barbara, CA 93106., R Garcia A; Scientific Research Core, Phoenix Children's Hospital, Phoenix, AZ 85016.; Department of Child Health, University of Arizona, Tucson, AZ 85724., Buetow K; Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, AZ 85287., Thomas GS; MemorialCare Health Systems, Fountain Valley, CA 92708.; Division of Cardiology, University of California, Irvine, Orange, CA 92868., Finch CE; Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089.; Department of Biological Sciences, Anthropology and Psychology, University of Southern California, Los Angeles, CA 90089., Stieglitz J; Institute for Advanced Study in Toulouse, Toulouse 1 Capitole University, Toulouse 31000, France., Trumble BC; Center for Evolution and Medicine, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287., Gurven MD; Department of Anthropology, University of California Santa Barbara, Santa Barbara, CA 93106., Irimia A; Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089.; Corwin D. Denney Research Center, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089.
Jazyk: angličtina
Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Mar 28; Vol. 120 (13), pp. e2205448120. Date of Electronic Publication: 2023 Mar 20.
DOI: 10.1073/pnas.2205448120
Abstrakt: Little is known about brain aging or dementia in nonindustrialized environments that are similar to how humans lived throughout evolutionary history. This paper examines brain volume (BV) in middle and old age among two indigenous South American populations, the Tsimane and Moseten, whose lifestyles and environments diverge from those in high-income nations. With a sample of 1,165 individuals aged 40 to 94, we analyze population differences in cross-sectional rates of decline in BV with age. We also assess the relationships of BV with energy biomarkers and arterial disease and compare them against findings in industrialized contexts. The analyses test three hypotheses derived from an evolutionary model of brain health, which we call the embarrassment of riches (EOR). The model hypothesizes that food energy was positively associated with late life BV in the physically active, food-limited past, but excess body mass and adiposity are now associated with reduced BV in industrialized societies in middle and older ages. We find that the relationship of BV with both non-HDL cholesterol and body mass index is curvilinear, positive from the lowest values to 1.4 to 1.6 SDs above the mean, and negative from that value to the highest values. The more acculturated Moseten exhibit a steeper decrease in BV with age than Tsimane, but still shallower than US and European populations. Lastly, aortic arteriosclerosis is associated with lower BV. Complemented by findings from the United States and Europe, our results are consistent with the EOR model, with implications for interventions to improve brain health.
Databáze: MEDLINE