No NFATC2 fusion in simple bone cyst of the jaw.

Autor: Ong SLM; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Gomes IP; Department of Pathology, Biological Science Institute (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Baelde HJ; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Passador-Santos F; Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil., de Andrade BAB; Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil., Briaire-de Bruijn IH; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Cavalcante IL; Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil., Schreuder WH; Department of Oral and Maxillofacial Surgery/Head and Neck Surgery, Amsterdam University Medical Center/Antoni Van Leeuwenhoek Hospital, Amsterdam, The Netherlands., Cleton-Jansen AM; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Cleven AHG; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Pathology, University Medical Center Groningen, Groningen, The Netherlands., Szuhai K; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Gomes CC; Department of Pathology, Biological Science Institute (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Bovée JVMG; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: Histopathology [Histopathology] 2023 Aug; Vol. 83 (2), pp. 326-329. Date of Electronic Publication: 2023 Mar 20.
DOI: 10.1111/his.14905
Abstrakt: Aims: Simple Bone Cysts (SBCs) predominantly occur in long bones and 59% harbour NFATC2 rearrangements. Jaw SBC is rare and was previously referred to as traumatic bone cyst. It can rarely occur in association with cemento-osseous dysplasia (COD). To determine whether jaw SBCs represent the same entity as SBC of the long bones, or if they have a different molecular signature, we collected 48 jaw SBC cases of 47 patients to assess NFATC2 rearrangement.
Methods and Results: Out of the 48 cases, 36 could be used for fluorescence in-situ hybridization (FISH), of which nine (two of which associated with COD) were successful using an NFATC2 split probe. The remaining cases failed to show adequate FISH signals. All nine cases lacked NFATC2 rearrangement and five of these showed no detectable gene fusions using Archer FusionPlex.
Conclusion: In our study, NFATC2 rearrangement is absent in solitary jaw SBC (n = 7) and COD-associated SBC (n = 2). Our findings suggest that SBC presenting in the jaw is molecularly different from SBC in long bones. Future molecular studies may confirm the absence of clonal molecular aberrations in SBC of the jaw which would support a non-neoplastic, reactive origin.
(© 2023 The Authors. Histopathology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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