Dysregulation of miR-155 Expression in Professional Mixed Martial Arts (MMA) Fighters.
| Autor: | Cabrera D; Psychology, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA., Thompson K; Psychology, Nova Southeastern University, Davie, USA., Thomas JD; Psychology, Nova Southeastern University, Davie, USA., Peacock C; College of Health Care Sciences, Nova Southeastern University, Davie, USA., Antonio J; College of Health Care Sciences, Nova Southeastern University, Davie, USA., Tartar JL; Psychology, Nova Southeastern University, Davie, USA., Tartar A; Biological Sciences, Nova Southeastern University, Davie, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Feb 13; Vol. 15 (2), pp. e34944. Date of Electronic Publication: 2023 Feb 13 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.34944 |
| Abstrakt: | Psychological and physical stress can induce dysregulation of gene expression via changes in DNA methylation and microRNA (miRNA) expression. Such epigenetic modifications are yet to be investigated in professional Mixed Martial Arts (MMA) fighters subject to highly stressful training involving repetitive head impacts. This study examined differences in DNA methylation and miRNA expression in elite MMA fighters compared to active controls. Global methylation differences between groups were assessed via a LINE-1 assay. At the same time, PCR arrays were used to estimate differential expression in samples of 21 fighters and 15 controls for 192 different miRNAs associated with inflammatory diseases. An Independent-Samples t -Test found no significant difference in LINE-1 methylation between groups. However, an Independent-Samples Mann-Whitney U Test revealed a significant upregulation in the expression of miR-155 in MMA fighter plasma. Since miR-155 has been recognized as an important regulator of neuroinflammation, this dysregulation suggests a possible epigenetic mechanism responsible for chronic inflammation associated with professional-level MMA training. Consistent with other published works, this study highlights the potential of miR-155 not only as a biomarker for monitoring long-term health risks linked to head trauma but also as a target to remediate the impact of chronic neuroinflammation. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Cabrera et al.) |
| Databáze: | MEDLINE |
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