Blood Pressure Control and Prescription Pattern of Antihypertensive Drugs in Adherence to the 2020 International Society of Hypertension (ISH) Global Hypertension Practice Guidelines in Saudi Arabia: A Retrospective Study.

Autor: Rashikh MA; Department of Pharmacology, College of Medicine, Shaqra University, Dawadmi, SAU., Alruways AF; College of Medicine, Shaqra University, Dawadmi, SAU., Alotaibi HB; College of Medicine, Shaqra University, Dawadmi, SAU., Alotaibi NA; Department of Pediatrics, Dawadmi College of Medicine, Shaqra University, Riyadh, SAU., Almarshad F; Department of Internal Medicine, College of Medicine, Shaqra University, Shaqra, SAU., Alsaab SM; Department of Internal Medicine, College of Medicine, Shaqra University, Dawadmi, SAU., Alotaibi G; Department of Pharmacology, College of Pharmacy, Shaqra University, Dawadmi, SAU.
Jazyk: angličtina
Zdroj: Cureus [Cureus] 2023 Feb 14; Vol. 15 (2), pp. e34965. Date of Electronic Publication: 2023 Feb 14 (Print Publication: 2023).
DOI: 10.7759/cureus.34965
Abstrakt: Background Hypertension is the leading risk factor for cardiovascular disease and death. Appropriate treatment of hypertension is necessary to reduce mortality. A prescription-based study is one of the most influential and helpful methods to examine physicians' irrational prescribing practices. This study was designed to investigate the antihypertensive prescription of physicians and their adherence to the treatment guidelines, as well as the blood pressure (BP) control rate in a general hospital in the Kingdom of Saudi Arabia. Methodology A retrospective, cross-sectional study was conducted between February 2020 and June 2021 in an outpatient department. Patients diagnosed with hypertension as per the 2020 International Society of Hypertension guidelines and those who received antihypertensive drugs were included. Study data included prescriptions, patient's age, duration of hypertension, comorbidities, BP, drug therapy type, and antihypertensive class. Results Overall, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (67.1%) were the most prescribed agents, followed by dihydropyridine-calcium channel blockers (62.6%), diuretics (26.1%), and β-blockers (10.1%). Comorbid and stage 2 hypertensive patients mainly received combination therapy (51.6%) rather than monotherapy (48.4%). The study revealed an 83.5% prescription adherence to the treatment guidelines. However, non-adherence was encountered in monotherapy, polytherapy, and elderly-treated patient groups. A 66.4% (at target BP in all cases <140/90 mmHg) and 39.3% (at target BP in comorbid patients <130/80 mmHg) rate of BP control was observed. Furthermore, the rate of BP control was significantly associated with prescription adherence (χ 2 = 71.316; p < 0.001). Conclusions The degree of prescription adherence and rate of BP control were found to be compatible with other published hypertension studies. However, considerable scope exists for improvement in rational drug utilization and rate of BP control, particularly in high-risk patients. Therefore, treatment guidelines must be followed by clinicians to achieve BP goals and reduce cardiovascular events among the Saudi population.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2023, Rashikh et al.)
Databáze: MEDLINE