Correlation Between Intensity of Vimentin Immuno-expression in Young Women with Triple Negative Breast Cancer and Its Cliniocopathological Parameters.

Autor:	Lumongga F; Philosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.; Department of Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Dharmajaya R; Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Siregar KB; Department of Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Delyuzar; Department of Anatomical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Handjari DR; Department of Anatomical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Jusuf NK; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Munir D; Department of Ear, Nose and Throat, Head & Neck, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Asrul; Department of Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Jazyk:	angličtina
Zdroj:	Medical archives (Sarajevo, Bosnia and Herzegovina) [Med Arch] 2022 Dec; Vol. 76 (6), pp. 454-457.
DOI:	10.5455/medarh.2022.76.454-457
Abstrakt:	Background: Young breast cancer patients (≤40 years) have different unifying oncogenic signaling pathways when compared to older people. Vimentin is a filament intermediate. Vimentin expression has an important role in epithelial-to-mesenchymal transition (EMT) and cancer progression. Objective: The aim of this study was to assess the correlation between vimentin intensity and clinicopathological parameters in patients with triple negative breast cancer aged 40 years. Methods: Samples were taken from 45 paraffin blocks of patients with young woman with triple negative invasive breast cancer NOS type that met the inclusion criteria, immunohistochemical examination was performed with vimentin. Vimentin intensity was assessed using ImageJ analysis. Results: Samples were taken from paraffin blocks of patients with triple negative invasive breast cancer NOS type that met the inclusion criteria, immunohistochemical examination was performed with vimentin. Vimentin intensity was assessed using ImageJ analysis. Conclusion: This study shows that vimentin intensity is strongly associated with tumor progression, tumor mass size and tumor invasion so that it can be used as a prognostic factor in young triple negative breast cancer patients. Competing Interests: The author declare that there is no conflict of interest. (© 2022 Fitriani Lumongga, Ridha Dharmajaya, Kamal Basri Siregar, Delyuzar, Diah Rini Handjari, Nelva Karmila Jusuf, Delfitri Munir, Asrul.)
Databáze:	MEDLINE
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