Twendee X, a mixed antioxidant supplement, improves cognitive function, coordination, and neurotrophic factor expression in long-term vitamin E-deficient mice.

Autor:	Fukui K; Molecular Cell Biology Laboratory, Department of Bioscience and Engineering, College of System Engineering and Science, Shibaura Institute of Technology, Fukasaku 307, Minuma-ku, Saitama 337-8570, Japan., You F; Division of Anti-oxidant Research, Life Science Research Center, Gifu University, Yanagito 1-1, Gifu 501-1194, Japan.; Anti-oxidant Research Laboratory, Louis Pasteur Center for Medical Research, Tanakamonzen-cho 103-5, Sakyo-ku, Kyoto 606-8225, Japan., Kato Y; Molecular Cell Biology Laboratory, Department of Bioscience and Engineering, College of System Engineering and Science, Shibaura Institute of Technology, Fukasaku 307, Minuma-ku, Saitama 337-8570, Japan., Kimura M; Molecular Cell Biology Laboratory, Department of Bioscience and Engineering, College of System Engineering and Science, Shibaura Institute of Technology, Fukasaku 307, Minuma-ku, Saitama 337-8570, Japan., Harakawa Y; Division of Anti-oxidant Research, Life Science Research Center, Gifu University, Yanagito 1-1, Gifu 501-1194, Japan., Yoshikawa T; Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.; Louis Pasteur Center for Medical Research, Tanakamonzen-cho 103-5, Sakyo-ku, Kyoto 606-8225, Japan., Inufusa H; Division of Anti-oxidant Research, Life Science Research Center, Gifu University, Yanagito 1-1, Gifu 501-1194, Japan.; Anti-oxidant Research Laboratory, Louis Pasteur Center for Medical Research, Tanakamonzen-cho 103-5, Sakyo-ku, Kyoto 606-8225, Japan.
Jazyk:	angličtina
Zdroj:	Journal of clinical biochemistry and nutrition [J Clin Biochem Nutr] 2023 Mar; Vol. 72 (2), pp. 93-100. Date of Electronic Publication: 2022 Dec 09.
DOI:	10.3164/jcbn.22-55
Abstrakt:	Oxidation products gradually accumulate during senescence, enhancing the risk of onset of many severe diseases. One such disease is dementia, and the number of cases of dementia, including Alzheimer's disease, has been increasing world-wide. These diseases can be prevented via attenuation of age-related physiological dysfunction; one preventive approach is the ingestion of antioxidants such as vitamin C and vitamin E. Many antioxidants are readily available commercially. Ingestion of mixed antioxidants is expected to provide further beneficial effects for human health. In this study, we used vitamin E-deficient mice as an animal model of increased oxidative stress and assessed the effects of dosing with mixed antioxidants. Administration of a commercial mixed antioxidant formula, Twendee X significantly improved cognitive function and coordination compared to untreated vitamin E-deficient animals. Furthermore, the levels of brain-derived neurotrophic factor and nerve growth factor were significantly increased in the cerebral cortex of Twendee X-dosed vitamin E-deficient mice compared to untreated animals. These results indicate that intake of a mixed antioxidant supplement may be beneficial to human health, even after oxidative stress has begun. In the next stage, it will be necessary to compare with other antioxidants and consider whether it is effective in the aged model. Competing Interests: FY, YH, and HI are employees of Gifu University. The Division of Anti-oxidant Research is a laboratory that has been established to the Life Science Research Center, Gifu University. based on a research fund from the TIMA establishment. There is Oxicut sold by the TIMA Tokyo INC. under the name of a product with a similar formulation, but it is different from the one used in this experiment. The Twendee X used in the experiment was not the product itself, but the one prescribed by Gifu University. FY, YH, and HI did not take every payment such as consulting, expert testimony, and do not have stock or stock options from TIMA Group. Some author photos are posted on the HP. But they haven’t received all the payments. TY is co-developing Twendee X with the TIMA Foundation and the TIMA Tokyo INC. The sponsor had no control over the interpretation, writing, or publication of this work. The other authors declare that they have no conflicts of interest to disclose. (Copyright © 2023 JCBN.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu