Aleppo galls alleviate paracetamol-induced hepatotoxicity and tissue damage: an experimental study.

Autor:	Abdallah AAM; Department of Biochemistry, Sohag Faculty of Medicine, Sohag University Sohag, Egypt.; Department of Basic Medical Sciences, Aqaba Medical Sciences University Aqaba, Jordan., Albadawi EA; Anatomy and Embryology Department, Taibah College of Medicine, Taibah University Al-Madinah, Saudi Arabia., Aboonq MS; Department of Medical Physiology, Taibah Faculty of Medicine, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia., Desouky MK; Anatomy and Embryology Department, Taibah College of Medicine, Taibah University Al-Madinah, Saudi Arabia.; Department of Anatomy, Minia Faculty of Medicine, Minia University Minia, Egypt., Ahmed AR; Department of Pathology, Sohag Faculty of Medicine, Sohag University Sohag, Egypt., Bafail R; Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia., Abdel-Halim OB; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia., AbdElmoniem MM; Department of Medical Biochemistry, National Research Center Cairo, Egypt., Aldhafiri AJ; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia., Alalawi A; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia., Omran FM; Department of Medical Pharmacology, Sohag Faculty of Medicine, Sohag University Sohag, Egypt., Abdellah WA; Department of Medical Pharmacology, Sohag Faculty of Medicine, Sohag University Sohag, Egypt., Abouelella AM; Department of Medical Pharmacology, Sohag Faculty of Medicine, Sohag University Sohag, Egypt., El-Sayed AA; Biology Department, Faculty of Science, Islamic University of Al-Madinah Al-Madinah Al-Munawwarah, Saudi Arabia.; Zoology Department, Faculty of Science, Zagazig University Zagazig, Egypt., Zaman AY; Department of Gynecology and Obstetrics, Taibah Faculty of Medicine, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia., Almohammadi N; Department of Pathology, Taibah Faculty of Medicine, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia., Al Thagfan SS; Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia., Abdel-Rahman IM; Department of Surgery, Al-Rayyan Medical Colleges Al-Madinah Al-Munawwarah, Saudi Arabia., Alsharif AM; Emergency & Trauma Unit, King Fahd Hospital Al-Madinah Al-Munawwarah, Saudi Arabia., Alanazi ME; Family Medicine & Diabetology Consultant, King Salman Bin Abdul-Aziz Medical City, Ministry of Health Al-Madinah Al-Munawwarah, Saudi Arabia., El Sayed SM; Department of Biochemistry, Sohag Faculty of Medicine, Sohag University Sohag, Egypt.; Department of Clinical Biochemistry and Molecular Medicine, Taibah Faculty of Medicine, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia., Baghdadi HH; Department of Clinical Biochemistry and Molecular Medicine, Taibah Faculty of Medicine, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia., Abdel-Latif HM; Department of Medical Pharmacology, Sohag Faculty of Medicine, Sohag University Sohag, Egypt.; Department of Medical Pharmacology, Al-Rayyan Medical Colleges Al-Madinah Al-Munawwarah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	International journal of biochemistry and molecular biology [Int J Biochem Mol Biol] 2023 Feb 15; Vol. 14 (1), pp. 1-9. Date of Electronic Publication: 2023 Feb 15 (Print Publication: 2023).
Abstrakt:	Background: Acute paracetamol toxicity is a common and potentially life-threatening emergency causing liver failure that may necessitate liver transplantation. Unfortunately, current therapies are still defective. Objectives: To investigate the protective effects exerted by Aleppo galls (Quercus infectoria Olivier) extract against acute paracetamol toxicity in mice. Methodology: Eighteen mice were divided into three experimental groups, each included six mice in each group. The groups included: negative control group, paracetamol toxicity group that received an acute toxic intraperitoneal dose of paracetamol (250 mg/kg) for four consecutive days, and treatment group (received 250 mg/kg paracetamol followed few hours later by Aleppo galls extract for the same duration). Animals were anaesthetized using ether anaesthesia. Animals were sacrificed by decapitation and blood samples were drawn. Paracetamol toxicity effects versus Aleppo galls protection were evaluated on liver function tests, liver histology, serum cholesterol and serum triglycerides. Results: Acute paracetamol toxicity caused significantly elevated serum transaminases (ALT and AST), decreased serum albumin, and increased serum cholesterol and triglycerides. Aleppo galls extract exerted significant protective effects and restored near normal serum levels of the previously-mentioned parameters. Upon histopathological evaluation, mice in the control group showed normal hepatic architecture with preserved hepatic cords and sinuses. Acute paracetamol toxicity induced peripheral zonal degeneration with focal necrosis of the hepatic tissue. The hepatocytes showed cytoplasmic vacuolation with indistinct cell borders. Central hepatic venules were congested. Administration of Aleppo galls extract reduced the tissue damaging effects induced by paracetamol toxicity with only minimal residual degenerative changes that were observed with absent necrosis. Conclusion: Quercus infectoria Olivier (Aleppo galls) is a promising source of phytochemicals and future therapeutics. Competing Interests: None. (IJBMB Copyright © 2023.)
Databáze:	MEDLINE
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