Role of the subthalamic nucleus in perceiving and estimating the passage of time.

Autor:	Honma M; Department of Medical Physiology, Kyorin University of School of Medicine, Tokyo, Japan., Sasaki F; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan., Kamo H; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan., Nuermaimaiti M; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan., Kujirai H; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan., Atsumi T; Department of Medical Physiology, Kyorin University of School of Medicine, Tokyo, Japan., Umemura A; Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan., Iwamuro H; Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan., Shimo Y; Department of Neurology, Juntendo University Nerima Hospital, Tokyo, Japan., Oyama G; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan., Hattori N; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan., Terao Y; Department of Medical Physiology, Kyorin University of School of Medicine, Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2023 Mar 02; Vol. 15, pp. 1090052. Date of Electronic Publication: 2023 Mar 02 (Print Publication: 2023).
DOI:	10.3389/fnagi.2023.1090052
Abstrakt:	Sense of time (temporal sense) is believed to be processed by various brain regions in a complex manner, among which the basal ganglia, including the striatum and subthalamic nucleus (STN), play central roles. However, the precise mechanism for processing sense of time has not been clarified. To examine the role of the STN in temporal processing of the sense of time by directly manipulating STN function by switching a deep brain stimulation (DBS) device On/Off in 28 patients with Parkinson's disease undergoing STN-DBS therapy. The test session was performed approximately 20 min after switching the DBS device from On to Off or from Off to On. Temporal sense processing was assessed in three different tasks (time reproduction, time production, and bisection). In the three temporal cognitive tasks, switching STN-DBS to Off caused shorter durations to be produced compared with the switching to the On condition in the time production task. In contrast, no effect of STN-DBS was observed in the time bisection or time reproduction tasks. These findings suggest that the STN is involved in the representation process of time duration and that the role of the STN in the sense of time may be limited to the exteriorization of memories formed by experience. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Honma, Sasaki, Kamo, Nuermaimaiti, Kujirai, Atsumi, Umemura, Iwamuro, Shimo, Oyama, Hattori and Terao.)
Databáze:	MEDLINE
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