Analysis of well-annotated next-generation sequencing data reveals increasing cases of SARS-CoV-2 reinfection with Omicron.

Autor: Burkholz S; Flow Pharma, Inc., Warrensville Heights, OH, USA., Rubsamen M; Case Western Reserve University, Cleveland, OH, USA., Blankenberg L; Texas A&M University, College Station, TX, USA., Carback RT 3rd; Flow Pharma, Inc., Warrensville Heights, OH, USA., Mochly-Rosen D; Stanford University School of Medicine, Department of Chemical and Systems Biology, Stanford, CA, USA., Harris PE; Flow Pharma, Inc., Warrensville Heights, OH, USA. peh1@columbia.edu.; Columbia University, Department of Medicine, College of Physicians and Surgeons, New York, NY, USA. peh1@columbia.edu.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2023 Mar 18; Vol. 6 (1), pp. 288. Date of Electronic Publication: 2023 Mar 18.
DOI: 10.1038/s42003-023-04687-4
Abstrakt: SARS-CoV-2 has extensively mutated creating variants of concern (VOC) resulting in global infection surges. The Omicron VOC reinfects individuals exposed to earlier variants of SARS-CoV-2 at a higher frequency than previously seen for non-Omicron VOC. An analysis of the sub-lineages associated with an Omicron primary infection and Omicron reinfection reveals that the incidence of Omicron-Omicron reinfections is occurring over a shorter time interval than seen after a primary infection with a non-Omicron VOC. Our analysis suggests that a single infection from SARS-CoV-2 may not generate the protective immunity required to defend against reinfections from emerging Omicron lineages. This analysis was made possible by Next-generation sequencing (NGS) of a Danish cohort with clinical metadata on both infections occurring in the same individual. We suggest that the continuation of COVID-19 NGS and inclusion of clinical metadata is necessary to ensure effective surveillance of SARS-CoV-2 genomics, assist in treatment and vaccine development, and guide public health recommendations.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje