Bio-efficacy of insecticidal molecule emodin against dengue, filariasis, and malaria vectors.

Autor: Chinnasamy R; Natural Drug Research Laboratory, Department of Biotechnology, School of Biosciences, Periyar University, Salem, Tamil Nadu, India.; Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India., Govindasamy B; Department of Research & Innovation, Saveetha School of Engineering (SSE), Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai Tamil Nadu, India., Venkatesh M; University of Texas Health Science Center, San Antonio, TX, USA., Magudeeswaran S; Department of Physics, Centre for Research and Development, KPR Institute of Engineering and Technology, Coimbatore, Tamil Nadu, India., Dhanarajan A; Molecular and Stress Physiology Laboratory, Department of Botany, School of Life Sciences, Periyar University, Salem, Tamil Nadu, India., Devarajan N; Natural Drug Research Laboratory, Department of Biotechnology, School of Biosciences, Periyar University, Salem, Tamil Nadu, India., Willie P; Institute of Environmental Sciences (CML), Leiden University, P.O. Box 9518, 2300 RA, Leiden, The Netherlands.; Center for Safety of Substances and Products, National Institute of Public Health and the Environment (RIVM), P.O. Box 1, Bilthoven, The Netherlands., Perumal V; Department of Entomology and Plant Pathology, Faculty of Agriculture, Chiang Mai University, Chiang Mai, 50200, Thailand.; Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 77, Tamil Nadu, India., Mekchay S; Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai, 50200, Thailand.; Innovative Agriculture Research Center, Faculty of Agriculture, Chiang Mai University, Chiang Mai, Thailand., Krutmuang P; Department of Entomology and Plant Pathology, Faculty of Agriculture, Chiang Mai University, Chiang Mai, 50200, Thailand. patcharink26@gmail.com.; Innovative Agriculture Research Center, Faculty of Agriculture, Chiang Mai University, Chiang Mai, Thailand. patcharink26@gmail.com.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2023 May; Vol. 30 (22), pp. 61842-61862. Date of Electronic Publication: 2023 Mar 18.
DOI: 10.1007/s11356-023-26290-0
Abstrakt: Emodin, a compound isolated from Aspergillus terreus, was studied using chromatographic and spectroscopic methods and compound purity (96%) was assessed by TLC. Furthermore, high larvicidal activity against Aedes aegypti-AeA (LC 50 6.156 and LC 90 12.450 mg/L), Culex quinquefasciatus-CuQ (8.216 and 14.816 mg/L), and Anopheles stephensi-AnS larvae (6.895 and 15.24 mg/L) was recorded. The first isolated fraction (emodin) showed higher pupicidal activity against AeA (15.449 and 20.752 mg/L). Most emodin-treated larvae (ETL) showed variations in acetylcholine esterase, α and β-carboxylesterases, and phosphatase activities in the 4 th instar, indicating the intrinsic differences in their biochemical changes. ETL had numerous altered tissues, including muscle, gastric caeca, hindgut, midgut, nerve ganglia, and midgut epithelium. Acute toxicity of emodin on brine shrimp Artemia nauplii (54.0 and 84.5 mg/L) and the zebrafish Danio rerio (less toxicity observed) was recorded. In docking studies, Emodin interacted well with odorant-binding-proteins of AeA, AnS, and CuQ with docking scores of - 8.89, - 6.53, and - 8.09 kcal mol -1 , respectively. Therefore, A. terreus is likely to be effective against mosquito larvicides.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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