Achievement of long-term lipid targets in a cohort of patients with acute coronary syndrome in real-world clinical practice.

Autor: Baldeón Conde C; Unidad de Lípidos y Riesgo Vascular, Servicio de Medicina Interna, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain. Electronic address: cristina.baldeon@scsalud.es., Royuela Martínez N; Servicio de Cardiología, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain., García Ibarbia C; Unidad de Lípidos y Riesgo Vascular, Servicio de Medicina Interna, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; Departamento de Medicina y Psiquiatría, Universidad de Cantabria, Santander, Cantabria, Spain; Instituto de Investigación Valdecilla (IDIVAL), Santander, Cantabria, Spain., Guerra Ruiz AR; Servicio de Análisis Clínicos, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain., Olavarri Miguel I; Servicio de Cardiología, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; Instituto de Investigación Valdecilla (IDIVAL), Santander, Cantabria, Spain., Cobo Belaustegui M; Servicio de Cardiología, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; Instituto de Investigación Valdecilla (IDIVAL), Santander, Cantabria, Spain., Alio Lavín B; Servicio de Análisis Clínicos, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; Instituto de Investigación Valdecilla (IDIVAL), Santander, Cantabria, Spain., González Vilchez FJ; Servicio de Cardiología, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; Instituto de Investigación Valdecilla (IDIVAL), Santander, Cantabria, Spain., de la Torre Hernández JM; Servicio de Cardiología, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; Departamento de Medicina y Psiquiatría, Universidad de Cantabria, Santander, Cantabria, Spain; Instituto de Investigación Valdecilla (IDIVAL), Santander, Cantabria, Spain., Hernández Hernández JL; Unidad de Lípidos y Riesgo Vascular, Servicio de Medicina Interna, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; Departamento de Medicina y Psiquiatría, Universidad de Cantabria, Santander, Cantabria, Spain; Instituto de Investigación Valdecilla (IDIVAL), Santander, Cantabria, Spain.
Jazyk: angličtina
Zdroj: Revista clinica espanola [Rev Clin Esp (Barc)] 2023 Apr; Vol. 223 (4), pp. 223-230. Date of Electronic Publication: 2023 Mar 16.
DOI: 10.1016/j.rceng.2023.02.011
Abstrakt: Introduction and Objectives: According to the recent European epidemiological studies, the degree of lipid control in patients with very high vascular risk is suboptimal. This study analyzes the epidemiological characteristics, cardiovascular risk factors, lipid profile, recurrence, and degree of achievement of long-term lipid targets, according to the ESC/EAS Guidelines, in a cohort of patients with acute coronary syndrome (ACS) in a real-world clinical practice setting.
Methods: This work is a retrospective cohort study of patients diagnosed with ACS admitted to the Coronary Unit of a tertiary hospital from January 1, 2012 to December 31, 2015 and followed-up on until March 2022.
Results: A total of 826 patients were studied. During the follow-up period, greater prescribing of combined lipid-lowering therapy was observed, mainly high- and moderate-intensity statins and ezetimibe. At 24 months after the ACS, 33.6% of living patients had LDL levels <70 mg/dl and 9.3% had LDL levels <55 mg/dl. At the end of the follow-up (101 [88-111] months), the corresponding figures were 54.5% and 21.1%. Some 22.1% of patients had a recurrent coronary event and only 24.6% achieved an LDL level <55 mg/dl.
Conclusions: Achievement of the LDL targets recommended by the ESC/EAS guidelines is suboptimal in patients with ACS, both at two years and in the long-term (7-10 years), especially in patients with recurrent ACS.
(Copyright © 2023. Published by Elsevier España, S.L.U.)
Databáze: MEDLINE
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