Developmental screening of full-term infants at 16 to 18 months of age after in-utero exposure to maternal SARS-CoV-2 infection.

Autor: Shah AV; Division of Neonatology, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA., Howell HB; Division of Neonatology, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA., Kazmi SH; Division of Neonatology, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA., Zaccario M; Division of Neonatology, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA.; Department of Psychology, Pace University, New York, NY, USA., Sklamberg FE; Division of Neonatology, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA., Groth T; Division of Neonatology, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA.; Rusk Rehabilitation, New York University Langone Health, New York, NY, USA., Martindale P; Division of Neonatology, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA., Dreyer B; Division of Developmental-Behavioral Pediatrics, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA., Verma S; Division of Neonatology, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA. sourabh.verma@nyulangone.org.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2023 May; Vol. 43 (5), pp. 659-663. Date of Electronic Publication: 2023 Mar 17.
DOI: 10.1038/s41372-023-01642-3
Abstrakt: Objective: To screen for neurodevelopmental delays in a cohort of full-term infants born to mothers with SARS-CoV-2.
Study Design: This was a prospective, descriptive cohort study of full-term infants born to mothers with SARS-CoV-2 during pregnancy. Subjects underwent neurodevelopmental screening using the Ages and Stages Questionnaires ® -Third Edition (ASQ ® -3) at 16 to 18 months age.
Results: Of 51 subjects, twelve (24%) were below cutoff, and twenty-seven (53%) were either below or close to the cutoff in at least one developmental domain. Communication (29%), fine motor (31%), and problem-solving (24%) were the most affected domains. There were no differences in outcomes between infants born to asymptomatic and mildly symptomatic mothers.
Conclusion: We observed increased risk of neurodevelopmental delays during screening of infants born at full-term to mothers with SARS-CoV-2 at 16 to 18 months age. These results highlight the urgent need for follow-up studies of infants born to mothers with SARS-CoV-2.
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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