Recurrence rate and survival implications of surgical margins in patients with acral melanoma. Is a wide margin necessary?

Autor:	Lino-Silva LS; Department of Oncological Pathology, Instituto Nacional de Cancerología, Mexico City., Hernández-Romero R; Department of Surgical Oncology, Instituto Nacional de Cancerología, Mexico City., García-Herrera JS; Department of Surgical Oncology, Instituto Nacional de Cancerología, Mexico City., Zepeda-Najar C; Department of Surgical Oncology, Hospital Ángeles Tijuana, Baja California. Mexico., Salcedo-Hernández RA; Department of Surgical Oncology, Instituto Nacional de Cancerología, Mexico City., León-Takahashi AM; Department of Surgical Oncology, Instituto Nacional de Cancerología, Mexico City., Escobar-Jiménez MG; Department of Oncological Pathology, Instituto Nacional de Cancerología, Mexico City., Herrera-Gómez Á; Department of Surgical Oncology, Instituto Nacional de Cancerología, Mexico City.
Jazyk:	angličtina
Zdroj:	Gaceta medica de Mexico [Gac Med Mex] 2023; Vol. 159 (1), pp. 38-43.
DOI:	10.24875/GMM.M22000734
Abstrakt:	Introduction: Appropriate size of resection margins in acral melanoma is not clearly established. Objective: To investigate whether narrow-margin excision is appropriate for thick acral melanoma. Methods: Three-hundred and six patients with acral melanoma were examined. Factors associated with recurrence and survival were analyzed according to surgical margin size (1 to 2 cm and > 2 cm). Results: Out of 306 patients, 183 were women (59.8%). Median Breslow thickness was 6 mm; 224 cases (73.2%) were ulcerated, 154 patients (50.3%) had clinical stage III disease, while 137 were at stage II (44.8%) and 15 at stage IV (4.9%). All cases had negative margins, with a median of 31.5 mm. A Breslow thickness of 7 mm (p = 0.001) and clinical stage III (p = 0.031) were associated with recurrence; the factors associated with survival were Breslow index (p = 0.047), ulceration (p = 0.003), advanced clinical stage (p < 0.001), and use of adjuvant therapy (p = 0.003). Conclusion: A resection margin of 1 to 2 cm did not affect tumor recurrence or survival in patients with acral melanoma. (Copyright: © 2023 Permanyer.)
Databáze:	MEDLINE
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