Gestational exposure to continuous light impairs the development of the female reproductive system in adult Wistar rat offspring.

Autor: Ogo FM; Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil.; Department of Pathological Sciences, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil., Siervo GEML; Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil.; Department of Pathological Sciences, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil., Praxedes AM; Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil., Vieira HR; Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil., da Silva Scarton SR; Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil.; Department of Pathological Sciences, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil., Bitencourt ATG; Department of Biological and Health Sciences, State University of Western Parana, Cascavel, Brazil., Arena AC; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista - Botucatu (UNESP), Botucatu, Brazil., Simão ANC; Department of Pathology, Clinical Analysis and Toxicology, Health Center, State University of Londrina - UEL, Londrina, Brazil., Guerra MT; Department of Cell Biology, Embryology and Histology, Federal University of Mato Grosso do Sul - UFMS, Três Lagoas, Brazil., de Freitas Mathias PC; Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil., Fernandes GSA; Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil.
Jazyk: angličtina
Zdroj: Birth defects research [Birth Defects Res] 2023 Apr 15; Vol. 115 (7), pp. 710-721. Date of Electronic Publication: 2023 Mar 17.
DOI: 10.1002/bdr2.2161
Abstrakt: Introduction: It has been suggested that maternal exposure to constant light during the gestational period could be considered as a chronic stressor, impairing offspring development by interfering in neuroendocrine and behavior responses.
Objective: This study aimed to evaluate whether maternal exposure to continuous light during pregnancy affects the adult reproductive system in the female offspring.
Materials and Methods: Pregnant Wistar rats were allocated into light-dark (LD) group, exposed to light and dark photoperiod during gestation, and the light-light (LL) group, exposed to a photoperiod of constant light during gestation. After birth, pups were maintained under normal light-dark photoperiod until adulthood. At postnatal day 90, blood was collected from the female offspring, to analyze plasma luteinizing hormone (LH) and progesterone levels, and the uterus and ovaries were harvested for morphometric, histological, and oxidative stress evaluations.
Results and Discussion: Female exposure to continuous light during the intrauterine period resulted in the adult reduction of LH and increased progesterone plasma levels, and uterine injuries a higher number of endometrial glands and reduced levels of antioxidant enzymes, such as glutathione reductase and glutathione S-transferase. In these experimental conditions, gestational continuous light exposure disturbs sex hormone balance and reduces the antioxidant enzymatic activity in the uterus of female offspring in adult life.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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