Chemical Profile and Cytotoxicity Evaluation of Aerial Parts of Marrubium vulgare L. From Different Locations in Turkey.
| Autor: | Demiroz Akbulut T; Department of Pharmaceutical Botany, Faculty of Pharmacy, Ege University, 35040, Izmir, Turkey., Aydin Kose F; Department of Biochemistry, Faculty of Pharmacy, Izmir Katip Celebi University, 35620, Izmir, Turkey., Demirci B; Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470, Eskisehir, Turkey., Baykan S; Department of Pharmaceutical Botany, Faculty of Pharmacy, Ege University, 35040, Izmir, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry & biodiversity [Chem Biodivers] 2023 Apr; Vol. 20 (4), pp. e202201188. Date of Electronic Publication: 2023 Mar 24. |
| DOI: | 10.1002/cbdv.202201188 |
| Abstrakt: | Marrubium vulgare L. (Lamiaceae) is used for respiratory and gastrointestinal system disorders in folk medicine. According to European Pharmacopoeia criteria, standardization of the plant is defined by its marrubiin content. In present study, phenolics, marrubiin and essential oil compositions of M. vulgare from different locations in Turkey were analyzed quantitatively by UPLC, GC and GC/MS. Besides, their cytotoxic potentials were evaluated. In the samples, forsythoside B (77-400 mg/100 g dw), arenarioside (forsythoside F) (0-241 mg/100 g dw), verbascoside (acteoside) (171-416 mg/100 g dw) and apigenin-7-O-glucoside (0-17 mg/100 g dw) were determined in different ranges. Marrubiin contents (0.58-1.46 %) of some samples were two times higher than European Pharmacopoeia standards (0.7 %). β-Caryophyllene (7.24-20.34 %), (Z)-β-farnesene (1.58-34.85 %), germacrene D (9.8-13.37 %), bicyclogermacrene (1.71-8.63 %) and β-bisabolene (0-16.68 %) were detected as major compounds in essential oils. The sample from the west of Aegean Region showed cytotoxicity against human neuroblastoma (SH-SY5Y) cell lines (IC (© 2023 Wiley-VHCA AG, Zurich, Switzerland.) |
| Databáze: | MEDLINE |
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