| Autor: |
Corona-Rivera J; Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Biología Mole-cular y Genómica, Instituto de Genética Humana Dr. Enrique Corona-Rivera, Guadalajara, Jalisco, México. rocorona@cucs.udg.mx., Peña-Padilla C; Hospital Civil de Guadalajara Dr. Juan I. Menchaca, División de Pediatría, Servicio de Genética, Guadalajara, Jalisco, México., Morales-Domínguez GE; Hospital Civil de Guadalajara Dr. Juan I. Menchaca, División de Pediatría, Servicio de Genética, Guadalajara, Jalisco, México., Romero-Bolaño YM; Hospital Civil de Guadalajara Dr. Juan I. Menchaca, División de Pediatría, Servicio de Genética, Guadalajara, Jalisco, México. |
| Abstrakt: |
Asthma is an etiologically heterogeneous disease resulting from a complex interaction between genetic. The genetic aspects involved in asthma, which were analyzed from the perspective of the traditional model of multifactorial inheritance, were susceptibility, host factors, and environmental exposures. In the present paper, studies on their family aggregation, concordance in twins, and heritability were analized; as well as the current knowledge about candidate genes, genome wide association studies, and epigenomics contributions and other omic studies that have increased our knowledge about their pathophysiology and environmental interactions. |
