Adherence to Hepatitis C Treatment Among Underserved Patients With Substance Use Disorder in a Pharmacist-led Treatment Model.

Autor:	McKenzie AJ; PGY2 Ambulatory Care Pharmacy Resident, Pharmacy Services, Family Medicine at Richmond Clinic, Oregon Health & Science University, Portland, OR, USA., Noble BN; Senior Faculty Research Assistant, Department of Pharmacy Practice, Oregon State University College of Pharmacy, Portland, OR, USA., Herink MC; Clinical Associate Professor, Department of Pharmacy Practice, Oregon State University College of Pharmacy, Portland, OR, USA., Viehmann MM; Pharmacy Operations Manager Family Medicine at Richmond Clinic, Oregon Health & Science University, Portland, OR, USA., Furuno JP; Professor, Department of Pharmacy Practice, Oregon State University College of Pharmacy, Portland, OR, USA.
Jazyk:	angličtina
Zdroj:	Journal of pharmacy practice [J Pharm Pract] 2024 Jun; Vol. 37 (3), pp. 637-643. Date of Electronic Publication: 2023 Mar 16.
DOI:	10.1177/08971900231165172
Abstrakt:	BackgroundTreatment with medications for opioid use disorder (MOUD) may improve hepatitis C virus (HCV) treatment outcomes by providing additional contact with health care professionals to support patient engagement. Objective: We describe a pharmacist-led HCV treatment model and assessed the effect of MOUD on adherence to direct-acting antivirals (DAAs) in an underserved patient population. Methods: This was a retrospective cohort study of adults (age≥18 years) treated for HCV infection with DAAs at a Federally Qualified Health Center in Portland, Oregon, between March 1, 2019, and March 16, 2020. Patients were followed to 12 weeks to assess adherence to DAAs by MOUD status. Results: Among 59 eligible patients, 16 (27%) were prescribed MOUD. Baseline characteristics were similar between patients who did and did not receive MOUD. Adherence to DAAs was overall high and not significantly different between the groups (median: 98.5% vs median: 100%; P = .06). Five patients missed at least one dose due to an adverse drug effect and two of these patients discontinued HCV therapy due to these effects. Conclusion: Adherence to HCV therapy was nearly 100% among underserved patients in a pharmacist-led HCV treatment model and did not differ by MOUD engagement. Competing Interests: Conflicts of InterestAll authors report no financial support or personal connections that could be perceived to bias their work.
Databáze:	MEDLINE
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