Prognostic factors and the prognostic role of inflammation indices in malignant pleural mesothelioma.

Autor:	Ebinç S; Department of Internal Medicine, Division of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye., Oruç Z; Department of Internal Medicine, Division of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye., Kalkan Z; Department of Internal Medicine, Division of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye., Karhan O; Department of Internal Medicine, Division of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye., Urakçı Z; Department of Internal Medicine, Division of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye., Küçüköner M; Department of Internal Medicine, Division of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye., Kaplan MA; Department of Internal Medicine, Division of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye., Abdurrahman I; Department of Internal Medicine, Division of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye.
Jazyk:	angličtina
Zdroj:	Turk gogus kalp damar cerrahisi dergisi [Turk Gogus Kalp Damar Cerrahisi Derg] 2023 Jan 30; Vol. 31 (1), pp. 105-115. Date of Electronic Publication: 2023 Jan 30 (Print Publication: 2023).
DOI:	10.5606/tgkdc.dergisi.2023.23365
Abstrakt:	Background: In this study, we aimed to investigate the prognostic factors of malignant pleural mesothelioma and the prognostic value of inflammation indices in malignant pleural mesothelioma. Methods: Between January 2002 and December 2019, a total of 132 patients (74 males, 58 females; mean age: 55 years; range, 31 to 79 years) diagnosed with malignant pleural mesothelioma were retrospectively analyzed. Patients" demographic data and laboratory results were recorded. The prognostic value of the following five inflammation indices was evaluated: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, advanced lung cancer inflammation index, C-reactive protein/albumin ratio, and prognostic nutritional index. Results: Of all patients, 81% (n=107) were aged 65 or older and 61.4% (n=81) had an epithelioid histology. Of 12 variables examined in the multivariate analysis for their relationship with survival, age ≥65 years, non-epithelioid subtype, and prognostic nutritional index <40 were found to be poor prognostic factors. Based on the score constructed from these factors, the good prognostic group (score 0-1) had a median overall survival of 21 months and a one-year survival rate of 77.9%, while the poor prognostic group (score 2-3) had a median overall survival of nine months and a one-year survival rate of 29.7%. Conclusion: Our study results indicate that age ≥65 years, prognostic nutritional index <40, and non-epithelioid histological subtype are poor prognostic factors of malignant pleural mesothelioma. Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article. (Copyright © 2023, Turkish Society of Cardiovascular Surgery.)
Databáze:	MEDLINE
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