Testing the Ecophenotype Model: Cortical Structure Alterations in Conduct Disorder With Versus Without Childhood Maltreatment.

Autor: Staginnus M; Department of Psychology, University of Bath, Bath, United Kingdom. Electronic address: ms2290@bath.ac.uk., Cornwell H; Department of Psychology, University of Bath, Bath, United Kingdom., Toschi N; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata,' Rome, Italy; Athinoula A. Martinos Center for Biomedical Imaging and Harvard Medical School, Boston, Massachusetts., Oosterling M; Department of Psychology, University of Bath, Bath, United Kingdom., Paradysz M; Department of Psychology, University of Bath, Bath, United Kingdom., Smaragdi A; Child Development Institute, Toronto, Ontario, Canada., González-Madruga K; Department of Psychology, Middlesex University, London, United Kingdom., Pauli R; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, United Kingdom., Rogers JC; Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, United Kingdom., Bernhard A; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany., Martinelli A; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany; School of Psychology, Fresenius University of Applied Sciences, Frankfurt, Germany., Kohls G; Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, RWTH Aachen, Aachen, Germany; Department of Child and Adolescent Psychiatry, Medical Faculty, TU Dresden, Dresden, Germany., Raschle NM; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland., Konrad K; Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, RWTH Aachen, Aachen, Germany; JARA-Brain Institute II, Molecular Neuroscience and Neuroimaging, RWTH Aachen and Research Centre Juelich, Juelich, Germany., Stadler C; Department of Child and Adolescent Psychiatry, Psychiatric University Hospital, University of Basel, Basel, Switzerland., Freitag CM; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany., De Brito SA; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, United Kingdom., Fairchild G; Department of Psychology, University of Bath, Bath, United Kingdom.
Jazyk: angličtina
Zdroj: Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2023 Jun; Vol. 8 (6), pp. 609-619. Date of Electronic Publication: 2023 Jan 02.
DOI: 10.1016/j.bpsc.2022.12.012
Abstrakt: Background: Childhood maltreatment is common in youths with conduct disorder (CD), and both CD and maltreatment have been linked to neuroanatomical alterations. Nonetheless, our understanding of the contribution of maltreatment to the neuroanatomical alterations observed in CD remains limited. We tested the applicability of the ecophenotype model to CD, which holds that maltreatment-related psychopathology is (neurobiologically) distinct from psychopathology without maltreatment.
Methods: Surface-based morphometry was used to investigate cortical volume, thickness, surface area, and gyrification in a mixed-sex sample of participants with CD (n = 114) and healthy control subjects (HCs) (n = 146), ages 9 to 18 years. Using vertexwise general linear models adjusted for sex, age, total intracranial volume, and site, the control group was compared with the overall CD group and the CD subgroups with (n = 49) versus without (n = 65) maltreatment (assessed by the Children's Bad Experiences interview). These subgroups were also directly compared.
Results: The overall CD group showed lower cortical thickness in the right inferior frontal gyrus. CD youths with a history of maltreatment showed more widespread structural alterations relative to HCs, comprising lower thickness, volume, and gyrification in inferior and middle frontal regions. Conversely, CD youths with no history of maltreatment only showed greater left superior temporal gyrus folding relative to HCs. When contrasting the CD subgroups, those with maltreatment displayed lower right superior temporal gyrus volume, right precentral gyrus surface area, and gyrification in frontal, temporal, and parietal regions.
Conclusions: Consistent with the ecophenotype model, findings indicated that CD youths with versus without maltreatment differ neurobiologically. This highlights the importance of considering maltreatment history in neuroimaging studies of CD and other disorders.
(Copyright © 2023 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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