Comparison of Tumor Size and Gene Expression at Presentation in Uveal Melanoma Patients before and during the COVID-19 Pandemic.
| Autor: | Hasegawa N; aDepartment of Ophthalmology, University of Texas at Houston, Houston, Texas, USA., Rusakevich A; bRetina Consultants of Texas, Houston, Texas, USA., Bernicker E; cHouston Methodist Cancer Center, Houston Methodist Hospital, Houston, Texas, USA., Teh BS; dDepartment of Radiation Oncology, Houston Methodist Hospital, Houston, Texas, USA., Schefler A; bRetina Consultants of Texas, Houston, Texas, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Ocular oncology and pathology [Ocul Oncol Pathol] 2022 Nov; Vol. 8 (3), pp. 156-160. Date of Electronic Publication: 2022 May 09. |
| DOI: | 10.1159/000524918 |
| Abstrakt: | Introduction: The aim of this study was to compare the clinical and gene expression variables of uveal melanoma patients presenting before and after the start of the COVID-19 pandemic as surrogate markers in order to assess the pandemic's potential impact on care. Methods: We conducted a retrospective chart review of uveal melanoma patients at Retina Consultants of Texas and assessed tumor size, staging, and gene expression data during two time periods: May 2019 to February 2020 (Group 1: Before the COVID-19 pandemic declaration by the WHO in March 2020) and May 2020 to March 2021 (Group 2: After the start of the COVID-19 pandemic). Results: A total of 80 patients with uveal melanoma were studied (Group 1: 40 [50%] and Group 2: 40 [50%]). There was no statistically significant difference in the tumor thickness ( p = 0.768), largest base dimension ( p = 0.758), Collaborative Ocular Melanoma Study size class ( p = 0.762), and American Joint Committee on Cancer stages ( p = 0.872) between the two groups. Additionally, there was no difference in the tumors' gene expression data including gene expression profile class ( p = 0.587) and PRAME expressivity ( p = 0.861) between the two groups. Discussion/Conclusion: The COVID-19 pandemic had no effect on the presentation of uveal melanoma patients across all tumor characteristics including size, staging, and gene expression data, suggesting there was not a significant diagnostic delay in care for uveal melanoma patients at our center due to the pandemic. (© 2022 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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