Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000-2012).

Autor: Ambrosioni J; Infectious Diseases Service, Hospital Clinic-IDIBAPS, University of Barcelona, Villarroel 170, 08032, Barcelona, Spain. jambrosioni@intramed.net.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain. jambrosioni@intramed.net., Hernández-Meneses M; Infectious Diseases Service, Hospital Clinic-IDIBAPS, University of Barcelona, Villarroel 170, 08032, Barcelona, Spain., Durante-Mangoni E; Department of Precision Medicine, University of Campania 'L. Vanvitelli', Monaldi Hospital, Naples, Italy., Tattevin P; Infectious Diseases and ICU, Pontchaillou University Hospital, Rennes, France., Olaison L; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden., Freiberger T; Centre of Cardiovascular Surgery and Transplantation, Brno, Czech Republic.; Medical Faculty, Masaryk University, Brno, Czech Republic., Hurley J; Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland., Hannan MM; Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland., Chu V; Duke University School of Medicine, Durham, NC, USA., Hoen B; Department of Infectious Diseases and Tropical Medicine and Inserm CIC-1424, University of Lorraine Medical Center at Nancy, EA 4364 APEMAC, University of Lorraine, Nancy, France., Moreno A; Infectious Diseases Service, Hospital Clinic-IDIBAPS, University of Barcelona, Villarroel 170, 08032, Barcelona, Spain., Cuervo G; Infectious Diseases Service, Hospital Clinic-IDIBAPS, University of Barcelona, Villarroel 170, 08032, Barcelona, Spain., Llopis J; Biostatistics Department, Faculty of Biology, University of Barcelona, Barcelona, Spain., Miró JM; Infectious Diseases Service, Hospital Clinic-IDIBAPS, University of Barcelona, Villarroel 170, 08032, Barcelona, Spain. jmmiro@ub.edu.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain. jmmiro@ub.edu.
Jazyk: angličtina
Zdroj: Infectious diseases and therapy [Infect Dis Ther] 2023 Apr; Vol. 12 (4), pp. 1083-1101. Date of Electronic Publication: 2023 Mar 15.
DOI: 10.1007/s40121-023-00763-8
Abstrakt: Introduction: Infective endocarditis (IE) has undergone important changes in its epidemiology worldwide.
Methods: The study aimed to compare IE epidemiological features and outcomes according to predefined European regions and between two different time periods in the twenty-first century.
Results: IE cases from 13 European countries were included. Two periods were considered: 2000-2006 and 2008-2012. Two European regions were considered, according to the United Nations geoscheme for Europe: Southern (SE) and Northern-Central Europe (NCE). Comparisons were performed between regions and periods. A total of 4195 episodes of IE were included, 2113 from SE and 2082 from NCE; 2787 cases were included between 2000 and 2006 and 1408 between 2008 and 2012. Median (IQR) age was 63.7 (49-74) years and 69.4% were males. Native valve IE (NVE), prosthetic valve IE (PVE), and device-related IE were diagnosed in 68.3%, 23.9%, and 7.8% of cases, respectively; 52% underwent surgery and 19.3% died during hospitalization. NVE was more prevalent in NCE, whereas device-related IE was more frequent in SE. Higher age, acute presentation, hemodialysis, cancer, and diabetes mellitus all were more prevalent in the second period. NVE decreased and PVE and device-related IE both increased in the second period. Surgical treatment also increased from 48.7% to 58.4% (p < 0.01). In-hospital and 6-month mortality rates were comparable between regions and significantly decreased in the second period.
Conclusions: Despite an increased complexity of IE cases, prognosis improved in recent years with a significant decrease in 6-month mortality. Outcome did not differ according to the European region (SE versus NCE).
(© 2023. The Author(s).)
Databáze: MEDLINE
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