CD4 + T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12.

Autor: Paust HJ; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Song N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., De Feo D; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland., Asada N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Tuzlak S; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland., Zhao Y; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg 20246, Germany., Riedel JH; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Hellmig M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Sivayoganathan A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Peters A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Kaffke A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Borchers A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Wenzel UO; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Steinmetz OM; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Tiegs G; Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Meister E; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Mack M; Department of Nephrology, University Hospital Regensburg, Regensburg 93042, Germany., Kurts C; Institute of Molecular Medicine and Experimental Immunology, University Hospital Bonn, Bonn 53127, Germany., von Vietinghoff S; Nephrology Section, Medical Clinic 1, University Hospital Bonn, Bonn 53127, Germany., Lindenmeyer MT; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Hoxha E; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Stahl RAK; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Bonn S; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Meyer-Schwesinger C; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Wiech T; Institute of Pathology, Division of Nephropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Turner JE; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Becher B; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland., Krebs CF; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Panzer U; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Jazyk: angličtina
Zdroj: Science translational medicine [Sci Transl Med] 2023 Mar 15; Vol. 15 (687), pp. eadd6137. Date of Electronic Publication: 2023 Mar 15.
DOI: 10.1126/scitranslmed.add6137
Abstrakt: GM-CSF in glomerulonephritisDespite glomerulonephritis being an immune-mediated disease, the contributions of individual immune cell types are not clear. To address this gap in knowledge, Paust et al . characterized pathological immune cells in samples from patients with glomerulonephritis and in samples from mice with the disease. The authors found that CD4+ T cells producing granulocyte-macrophage colony-stimulating factor (GM-CSF) licensed monocytes to promote disease by producing matrix metalloproteinase 12 and disrupting the glomerular basement membrane. Targeting GM-CSF to inhibit this axis reduced disease severity in mice, implicating this cytokine as a potential therapeutic target for patients with glomerulonephritis. -CM.
Databáze: MEDLINE