Tandem high-dose chemotherapy followed by autologous stem cell transplantation: An infant with trilateral retinoblastoma.

Autor: Toret E; Department of Pediatric Hematology-Oncology, Eskisehir Osmangazi University, School of Medicine, Eskisehir, Turkey., Ozdemir ZC; Department of Pediatric Hematology-Oncology, Eskisehir Osmangazi University, School of Medicine, Eskisehir, Turkey., Zengin Ersoy G; Department of Pediatric Hematology-Oncology, Altinbas University, School of Medicine, Medicalpark Bahcelievler Hospital, Istanbul, Turkey., Oztunali C; Department of Pediatric Radiology, Eskisehir Osmangazi University, School of Medicine, Eskisehir, Turkey., Bozkurt C; Department of Pediatric Hematology-Oncology, Istinye University, School of Medicine, Altınbas University Medicalpark Bahcelievler Hospital, Istanbul, Turkey., Kebudi R; Department of Pediatric Hematology-Oncology, Istanbul University Oncology Institute, Cerrahpasa School of Medicine, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Pediatric transplantation [Pediatr Transplant] 2023 Jun; Vol. 27 (4), pp. e14504. Date of Electronic Publication: 2023 Mar 15.
DOI: 10.1111/petr.14504
Abstrakt: Background: Retinoblastoma (RB) is the most common intraocular malignancy in childhood. Advanced RB, associated with exceedingly poor prognosis, requires more intensive multiagent chemotherapy than conventional regimens. Rescue of the bone marrow after intensive chemotherapy is achieved with stem cell transplantation. The sequential courses (tandem transplantation) of high-dose chemotherapy followed by autologous stem cell transplantation allow for even greater dose intensity in consolidation with the potential to use different active chemotherapeutics at each transplant and have proven feasible and successful in treating children with recurrent/refractory solid tumors.
Case Description: We report an infant with trilateral high-risk RB who received tandem high-dose chemotherapy (HDC) followed by autologous stem cell transplantation after the conventional chemotherapy. A 5-month-old female patient presented with strabismus, and the ophthalmoscopic examination showed intraocular tumoral lesions in both eyes. Magnetic resonance imaging (MRI) concluded the trilateral retinoblastoma diagnosis due to a tumoral mass in the optic chiasm. The follow-up ophthalmologic examinations and the MRI detected stable disease after six cycles of multiagent chemotherapy.
Conclusions: Rescue with autologous stem cell transplantation after HDC allows for an increase in chemotherapy intensity. Tandem transplantation provides the chance to perform different chemotherapeutics at each transplant and enables an increase in the chemotherapy intensity, thus providing a positive effect on disease-free survival.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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