Talarostatin, a vermistatin derivative from the soil-derived fungus Talaromyces thailandensis PSU-SPSF059.

Autor: Ningsih BNS; Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, Thailand.; Department of Chemistry, Faculty of Mathematics and Natural Science, University of Mataram, Mataram, West Nusa Tenggara, Indonesia., Rukachaisirikul V; Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, Thailand., Phongpaichit S; Division of Biological Science, Faculty of Science, Prince of Songkla University, Songkhla, Thailand., Muanprasat C; Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakarn, Thailand., Preedanon S; National Biobank of Thailand (NBT), National Science and Technology for Development Agency (NSTDA), Klong Luang, Pathum Thani, Thailand., Sakayaroj J; School of Science, Walailak University, Thasala, Nakhonsithammarat, Thailand., Intayot R; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, Thailand., Jungsuttiwong S; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, Thailand.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2024 Aug; Vol. 38 (15), pp. 2535-2542. Date of Electronic Publication: 2023 Mar 15.
DOI: 10.1080/14786419.2023.2188209
Abstrakt: The soil-derived fungus Talaromyces thailandensis PSU-SPSF059 produced one new vermistatin derivative, talarostatin, and seven known compounds including two vermistatins, two chrodrimanins, two diphenyl ethers and one penicillide derivative. Extensive spectroscopic analysis was performed to identify their structures. The absolute configuration of talarostatin was determined by comparing the experimental and calculated electronic circular dichroism data. The antimicrobial and cytotoxic activities of the isolated secondary metabolites were also evaluated.
Databáze: MEDLINE