Control of human cytomegalovirus replication by liver resident natural killer cells.

Autor: Forrest C; Institute of Immunity & Transplantation, UCL, London, NW3 2PP, UK., Chase TJG; Department of Surgery, UCL, Royal Free Campus, London, NW3 2PF, UK., Cuff AO; Department of Metabolism, Digestion and Reproduction, Imperial College London, Chelsea & Westminster Campus, London, SW10 9NH, UK., Maroulis D; Department of Surgery, UCL, Royal Free Campus, London, NW3 2PF, UK., Motallebzadeh R; Department of Surgery, UCL, Royal Free Campus, London, NW3 2PF, UK., Gander A; Department of Surgery, UCL, Royal Free Campus, London, NW3 2PF, UK., Davidson B; Department of Surgery, UCL, Royal Free Campus, London, NW3 2PF, UK., Griffiths P; Institute of Immunity & Transplantation, UCL, London, NW3 2PP, UK., Male V; Department of Metabolism, Digestion and Reproduction, Imperial College London, Chelsea & Westminster Campus, London, SW10 9NH, UK. v.male@imperial.ac.uk., Reeves M; Institute of Immunity & Transplantation, UCL, London, NW3 2PP, UK. matthew.reeves@ucl.ac.uk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Mar 14; Vol. 14 (1), pp. 1409. Date of Electronic Publication: 2023 Mar 14.
DOI: 10.1038/s41467-023-37181-w
Abstrakt: Natural killer cells are considered to be important for control of human cytomegalovirus- a major pathogen in immune suppressed transplant patients. Viral infection promotes the development of an adaptive phenotype in circulating natural killer cells that changes their anti-viral function. In contrast, less is understood how natural killer cells that reside in tissue respond to viral infection. Here we show natural killer cells resident in the liver have an altered phenotype in cytomegalovirus infected individuals and display increased anti-viral activity against multiple viruses in vitro and identify and characterise a subset of natural killer cells responsible for control. Crucially, livers containing natural killer cells with better capacity to control cytomegalovirus replication in vitro are less likely to experience viraemia post-transplant. Taken together, these data suggest that virally induced expansion of tissue resident natural killer cells in the donor organ can reduce the chance of viraemia post-transplant.
(© 2023. The Author(s).)
Databáze: MEDLINE
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