Effect of chronic exposure to fine particulate matter on cardiac tissue of NZBWF1 mice.
Autor: | Waked D; Laboratory of Environmental and Experimental Pathology, Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil., Rodrigues ACB; Laboratory of Environmental and Experimental Pathology, Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil., Silva TM; Laboratory of Environmental and Experimental Pathology, Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil., Yariwake VY; Laboratory of Environmental and Experimental Pathology, Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil., Farhat SCL; Laboratory of Environmental and Experimental Pathology, Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil.; Pediatric Rheumatology Unit, Children's Institute of Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Veras MM; Laboratory of Environmental and Experimental Pathology, Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil. |
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Jazyk: | angličtina |
Zdroj: | International journal of experimental pathology [Int J Exp Pathol] 2023 Aug; Vol. 104 (4), pp. 177-187. Date of Electronic Publication: 2023 Mar 14. |
DOI: | 10.1111/iep.12473 |
Abstrakt: | Epidemiological and toxicological studies have shown that inhalation of particulate matter (PM) is associated with development of cardiovascular diseases. Long-term exposure to PM may increase the risk of cardiovascular events and reduce life expectancy. Systemic lupus erythematosus (SLE) is a chronic inflammatory disease, autoimmune in nature, that is characterized by the production of autoantibodies that affects several organs, including the heart. Air pollution - which can be caused by several different factors - may be one of the most important points both at the onset and the natural history of SLE. Therefore this study aims to investigate whether exposure to air pollution promotes increased inflammation and cardiac remodelling in animals predisposed to SLE. Female NZBWF1 mice were exposed to an environmental particle concentrator. Aspects related to cardiac remodelling, inflammation and apoptosis were analysed in the myocardium. Body weight gain, cardiac trophism by heart/body weight ratio, relative area of cardiomyocytes and the fibrotic area of cardiac tissue were evaluated during the exposure period. Animals exposed to PM2.5 showed increased area of cardiomyocytes, and area of fibrosis; in addition, we observed an increase in IL-1 and C3 in the cardiac tissue, demonstrating increased inflammation. We suggest that air pollution is capable of promoting cardiac remodelling and increased inflammation in animals predisposed to SLE. (© 2023 Company of the International Journal of Experimental Pathology (CIJEP).) |
Databáze: | MEDLINE |
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