Recent Advances in Metal Complexes for Antimicrobial Photodynamic Therapy.

Autor: Rees TW; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Ho PY; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK., Hess J; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK.
Jazyk: angličtina
Zdroj: Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Aug 15; Vol. 24 (16), pp. e202200796. Date of Electronic Publication: 2023 Jul 17.
DOI: 10.1002/cbic.202200796
Abstrakt: Antimicrobial resistance (AMR) is a growing global problem with more than 1 million deaths due to AMR infection in 2019 alone. New and innovative therapeutics are required to overcome this challenge. Antimicrobial photodynamic therapy (aPDT) is a rapidly growing area of research poised to provide much needed help in the fight against AMR. aPDT works by administering a photosensitizer (PS) that is activated only when irradiated with light, allowing high spatiotemporal control and selectivity. The PS typically generates reactive oxygen species (ROS), which can damage a variety of key biological targets, potentially circumventing existing resistance mechanisms. Metal complexes are well known to display excellent optoelectronic properties, and recent focus has begun to shift towards their application in tackling microbial infections. Herein, we review the last five years of progress in the emerging field of small-molecule metal complex PSs for aPDT.
(© 2023 The Authors. ChemBioChem published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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