Protein-based Nanoparticles: From Drug Delivery to Imaging, Nanocatalysis and Protein Therapy.

Autor: Kaltbeitzel J; School of Chemical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.; Australian Centre for NanoMedicine, University of New South Wales, Sydney, NSW 2052, Australia., Wich PR; School of Chemical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.; Australian Centre for NanoMedicine, University of New South Wales, Sydney, NSW 2052, Australia.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Oct 26; Vol. 62 (44), pp. e202216097. Date of Electronic Publication: 2023 Jul 31.
DOI: 10.1002/anie.202216097
Abstrakt: Proteins and enzymes are versatile biomaterials for a wide range of medical applications due to their high specificity for receptors and substrates, high degradability, low toxicity, and overall good biocompatibility. Protein nanoparticles are formed by the arrangement of several native or modified proteins into nanometer-sized assemblies. In this review, we will focus on artificial nanoparticle systems, where proteins are the main structural element and not just an encapsulated payload. While under natural conditions, only certain proteins form defined aggregates and nanoparticles, chemical modifications or a change in the physical environment can further extend the pool of available building blocks. This allows the assembly of many globular proteins and even enzymes. These advances in preparation methods led to the emergence of new generations of nanosystems that extend beyond transport vehicles to diverse applications, from multifunctional drug delivery to imaging, nanocatalysis and protein therapy.
(© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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