Perianal basosquamous carcinoma treated with radiation therapy, a case report.

Autor:	Kwan SY; Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA., Castillo DR; Division of Hematology/Oncology, Loma Linda University Medical Center, Loma Linda, CA, USA., Aka AA; Division of Surgical Oncology, Loma Linda University Medical Center, Loma Linda, CA, USA., Kandala G; Department of Pathology, Loma Linda University Medical Center, Loma Linda, CA, USA., Tsai JY; Division of Hematology/Oncology, Loma Linda University Medical Center, Loma Linda, CA, USA., Zmaj K; Department of Surgery, Loma Linda VA Medical Center, Loma Linda, CA, USA., Reeves ME; Division of Surgical Oncology, Loma Linda University Medical Center, Loma Linda, CA, USA., Yang GY; Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA.
Jazyk:	angličtina
Zdroj:	Journal of gastrointestinal oncology [J Gastrointest Oncol] 2023 Feb 28; Vol. 14 (1), pp. 463-467. Date of Electronic Publication: 2023 Feb 24.
DOI:	10.21037/jgo-22-1244
Abstrakt:	Background: Perianal basal cell carcinoma (BCC) is very rare and estimated to account for 0.08% of all BCC and 0.02% of all anorectal neoplasms. Perianal lesions are more likely to be squamous cell carcinoma (SCC) as BCC usually develops on areas of skin exposed to ultraviolet (UV) light such as the face and arms. Proper diagnosis with the assistance of immunohistochemistry (IHC) stains to distinguish the two entities can help inform the suitable course of treatment. Case Description: Our case is an 82-year-old male with a history of cutaneous BCC on the arms and trunk presenting with a symptomatic perianal lesion. Initial biopsy demonstrated BCC with subsequent IHC studies differentiating from basaloid SCC. Standard treatment includes wide local excision (WLE) but given his poor performance status, radiation only was recommended. He was successfully treated and tolerated 30 Gy in 5 daily fractions. Conclusions: Radiation only is a unique and feasible non-surgical treatment for basosquamous carcinoma of the anus. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jgo.amegroups.com/article/view/10.21037/jgo-22-1244/coif). GYY serves as the current Editor-in-Chief of Journal of Gastrointestinal Oncology. The other authors have no conflicts of interest to declare. (2023 Journal of Gastrointestinal Oncology. All rights reserved.)
Databáze:	MEDLINE
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